急性脑出血患者血清C—FOS蛋白浓度升高的临床意义  

The serum concentration of C- FOS protein increased in patients with acute intracerebral hemorrhage

作　　者：秦海军[2] 张峰[1] 刘畅[1] 沈君妹[1] 

机构地区：[1]复旦大学附属金山医院急诊科,200540 [2]上海交通大学附属第六人民医院

出　　处：《神经疾病与精神卫生》2012年第3期257-260,共4页Journal of Neuroscience and Mental Health

摘　　要：目的研究急性脑出血患者血清中C—FOS蛋白浓度及其临床意义。方法采用酶联免疫吸附法（ELlSA）测定40例脑出血患者发病后12，24，48h和7d及40例健康人（正常对照组）血清c—FOS蛋白浓度，分析脑出血患者c—FOS蛋白浓度与神经系统功能缺损程度评分（NIHSS）、血肿体积和血肿周围水肿体积（PHE）及90d预后（改良的Rankin评分）之间的关系。结果脑出血组患者血清c—FOS浓度（8．59±5．29）ng／L高于正常对照组（0．85±0．47）ng／L（P〈0．01），且在1周内维持在较高水平；患者血清C—FOS浓度升高与NIHSS（r：0．50，P〈0．01；12h）、血肿体积（r=0．69，P〈0．01）、PHE（r=0．67，P〈0．01）及Rankin评分（r=0．78，P〈0．01）呈正相关；应用ROC曲线分析，以血清c—FOS浓度6．51ng／L为标准评估预后，敏感度为0．71，特异度为0．79。结论脑出血后血清c—FOS浓度增高，在一定程度上反映了患者的病情程度，有助于早期及90d预后的评估。Objective To investigate the serum concentration and clinical significance of C--FOS in patients with acute intracerebral hemorrhage（ICH）. Methods A total of 40 patients were included in this study. C-FOS concentration in the serum of 40 patients at admission （〈12 hours） and 40 normal control were determined by enzyme： linked immunosorbent assay （ELISA） ,and the relationship between the concentration of C-FOS and the degree of neurological impairment （NIHSS）, the volume of ICH and perihematomal edema volumes （PHE） and outcome were examined. Results The serum concentration of C-FOS protein level of patients was higher than that in the control group[（8.59 ± 5.29） ng/L versus （0.85±0.47）ng/L, P〈 0.01 ] ,and tt/is higher concentration of C--FOS was persistent in one week af- ter the initial attack. Furthermore, the higher level of C- FOS was positively correlated with NIHSS （r=0.50,P〈0.01,12h）,thevolumeofICH（r=0.69,P〈0.01）,PHE（r=0.67,P〈0.01）,and MRS （r = 0.78,P〈 0.01）. Using receiver operating characteristic （ROC） curve analysis,a cut-off point （6.51 ng/L） provided a sensitivity （0.71） and a specificity （0.79） for the identification of prognosis. Conclusions Increased C-FOS level is found after acute ICH and association with the severity and prognosis in the patients with ICH.

关 键 词：脑出血 预后 生物标记 C—FOS 

分 类 号：R473.5[医药卫生—护理学]