7-氨基去乙酰氧基头孢烷酸(7-ADCA)的合成研究 Ⅰ.青霉素G钾盐的氧化  

Study on the synthesis of 7-ADCA Ⅰ. The oxidation of penicillin G potassium salt

作　　者：刘东志[1] 曲红梅[1] 肖义[1] 李永刚[1] 周立山[1] 张伟[1] 

机构地区：[1]天津大学化工学院,天津300072

出　　处：《中国抗生素杂志》2000年第2期103-104,共2页Chinese Journal of Antibiotics

摘　　要：以青霉素 G钾为原料 ,分别采用过氧乙酸和双氧水作氧化剂合成青霉素 G亚砜 ,收率可达91.5 %。实验证实双氧水完全可以代替过氧乙酸。另外当反应结束后酸化至 p H2 .0时 ,青霉素 G亚砜就从反应液中直接结晶析出 ,从而解决了它与反应体系的分离问题。Penicillin G potassium salt can be oxidized by Hydrogen Peroxide or Peracetic acid to give sulfoxide with a yield of 91.5%. Results show that Hydrogen Peroxide can also be used as well as Peracetic acid. When the pH is 2.0, the formed sulfoxide can be crystallized from the solution by acidifying. Thus the separating problem can be resolved.

关 键 词：青霉素G钾 过氧乙酸 双氧水 青霉素G亚砜 

分 类 号：R978.11[医药卫生—药品] R914.5[医药卫生—药学]