三种碳青霉烯类抗生素的体外抗菌作用  

In vitro antibacterial activity of three agents of carbapenems

作　　者：杨帆[1] 张婴元[1] 吴卫红[1] 吴培澄[1] 周乐[1] 

机构地区：[1]上海医科大学华山医院抗生素研究所,上海200040

出　　处：《中国抗生素杂志》2000年第2期120-123,共4页Chinese Journal of Antibiotics

摘　　要：为评价亚胺培南、帕尼培南与美罗培南的体外抗菌作用 ,以琼脂对倍稀释法测定三者对 2 2 5株临床分离菌的最低抑菌浓度 (MIC) ,并与相关抗菌药物进行比较。结果 ,三种碳青霉烯类抗生素对肠杆菌科细菌具高度抗菌活性 ,对铜绿假单胞菌、不动杆菌属、粪肠球菌等亦具良好抗菌作用。帕尼培南与亚胺培南体外抗菌作用相仿 ,两者对肺炎克雷伯氏菌、肠杆菌属等革兰氏阴性菌作用略逊于美罗培南。三种碳青霉烯类抗生素体外抗菌作用优于头孢他啶、β-内酰胺类抗生素与β-内酰胺酶抑制剂合剂、氟喹诺酮类等其它受试药物。结果表明 ,碳青霉烯类抗生素是治疗多重耐药菌所致院内感染、免疫缺陷者感染和严重需氧菌与厌氧菌混合感染的适用药物。To evaluate the in vitro antimicrobial activity of imipenem, panipenem and meropenem. The minimum inhibitory concentrations (MIC) of imipenem, panipenem and meropenem for 225 clinical isolates was determined by agar dilution method, in comparison to 13 other antimicrobial agents. The three agents were highly active against Enterobacteriaceae , and they also possessed good antimicrobial activity against P.aeruginosa, Acinetobacter spp and E.faecalis . Panipenem and imipenem exhibited comparable in vitro antimicrobial activity, and their activity against gram negative bacteria such as K.pneumoniae and Enterobacter spp was slightly inferior to meropenem, superior to that of ceftazidime, fluroquinolones and β lactam and β lactamase inhibitor combinations. Carbapenems are the antibiotics of choice in treating hospital acquired infection caused by multi resistant bacteria, infection of immunocompromised patients and severe mixed infections of aerobic and anaerobic bacteria.

关 键 词：碳青霉烯类 抗生素 体外抗菌作用 

分 类 号：R978.11[医药卫生—药品]