植物多糖干预细胞黏附研究进展  

Research progresses of plant polysaccharides on cell adhesion

作　　者：徐先祥[1] 刁勇[1] 许瑞安[1] 孙爱静[1] 

机构地区：[1]华侨大学分子药物学研究所,福建泉州362021

出　　处：《药学学报》2012年第7期844-849,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(30600821);华侨大学引进人才科研启动项目(10BS324);华侨大学中央高校基本科研业务费专项(JB-SJ1012);泉州市科技计划项目(2011Z8)

摘　　要：黏附分子介导的细胞黏附是最基本的生命现象,也是炎症、免疫、感染、血栓形成、肿瘤转移、伤口愈合等生理病理过程的细胞学基础,干预黏附已成为疾病防治的重要策略。植物多糖特别是中草药中的多糖具有抗炎、抗肿瘤、抗感染、调节免疫、保护心血管等多样的药理作用,本文综述了植物多糖对疾病过程中细胞黏附的干预作用。Cell adhesion mediated by cell adhesion molecules （CAMs） constitutes essential life phenomenon. In inflammation, immunity, infection, thrombosis, tumor metastasis and wound healing, cell adhesion comes into being the basic physiological and pathological process. Intervening with cell adhesion has been the important therapeutic and prophylactic strategies for diseases. Accumulated evidence has indicated that plant polysaccharides especially those exacted from Chinese traditional and herbal drugs displayed various pharmacological effects such as anti-inflammation, anti-cancer, anti-infection, immunomodulation, cardiovascular protective effects and so on. In this paper, the research progress of plant polysaccharides on cell adhesion is reviewed.

关 键 词：植物多糖 细胞黏附 细胞黏附分子 

分 类 号：R966[医药卫生—药理学]