白细胞计数与脂类代谢性疾病的相关性分析  

Relationship between white blood cell count and lipoid metabolic diseases

作　　者：叶芳[1] 王继红[1] 

机构地区：[1]重庆医科大学实验教学中心生物化学与分子生物学实验室,重庆400016

出　　处：《中国老年学杂志》2012年第12期2451-2453,共3页Chinese Journal of Gerontology

基　　金：重庆市自然科学基金(No.CSTC2008CE9142);重庆医科大学创新基金(No.CX200528)

摘　　要：目的分析体检人群的白细胞计数(WBC)与血清甘油三酯(TG)、总胆固醇(TC)、性别、年龄之间的相关性。方法以重庆市40044例体检者为研究对象,检测其WBC、TG、TC含量,按照统计学四分位方法将WBC分为WBC1组、WBC2组、WBC3组、WBC4组,各组的WBC分别为0～4.90×109/L、(4.91～5.79)×109/L、(5.80～6.71)×109/L、>6.72×109/L,用SPSS17.0软件分析各WBC水平与血清TC、TG、性别和年龄的相关性,讨论其与相关疾病的关系。结果随着WBC计数增加,各组TG、TC含量以及男性比例均逐渐升高,女性比例逐渐降低(P<0.01);WBC1组WBC与TG、TC和性别呈正相关,与年龄负相关,相关系数(r)分别为0.121,0.044,0.099,-0.033(P<0.01);WBC2、WBC4两组的WBC也与TG、TC和性别呈正相关,r分别为0.074、0.037、0.035,0.084、0.03、0.042(P<0.01),与年龄不相关(P>0.05);WBC3组中WBC仅与TG相关(r=0.04,P<0.01),而与TC、性别和年龄都不相关(均P>0.05)。以WBC计数为因变量,TG、TC、性别和年龄为自变量进行多重线性回归分析,标准化偏回归系数(β)分别为0.123,0.035,0.117,-0.03(P<0.01)。结论重庆市民的WBC在一定范围内与TG、TC和性别有关,在此范围内的WBC有望成为脂代谢相关疾病辅助诊断的新指标。Objective To investigate the relationship between white blood cell count（WBCC） and blood fat in Chongqing people,and further to imply the correlation between WBCC and human lipoid metabolic diseases.Methods 40 044 subjects were enrolled from Chongqing.The levels of WBCC,triglyceride（TG） and total cholesterol（TC） were detected.The objects were divided into four groups according to WBCC（WBC1 ： 0 ～ 4.90 × 109 / L,WBC2 ： 4.91 × 109 ～ 5.79 × 109 / L,WBC3 ： 5.80 × 109 ～ 6.71 × 109 / L,WBC4 ： 6.72 × 109 ～ × 109 / L）.The SPSS software was used to analyze the relationship between serum TG,TC,gender,age and WBCC in different levels of WBCC.Results The TG,TC levels and constituent ratio of male were increased with higher WBCC,while the constituent of female was decreased（P 0.01）.WBCC was positively correlated to serum TG,TC and gender but negatively correlated to age in WBC1,r = 0.121,0.044,0.099,-0.033（P 0.01）.In WBC2 and WBC4,WBCC was positively correlated to serum TG,TC and gender too,r = 0.074,0.037,0.035,0.084,0.03,0.042（P 0.01）,while had no relationship with age（P 0.05）.The WBCC was only correlated to serum TG（r = 0.04,P 0.01） in WBC3,whereas had no correlation with TC,gender and age（P 0.05）.In multiple linear regression analysis,WBCC was selected as dependent variable and TG,TC,gender,age as independent variables.The standardized coefficients beta（β） were 0.123,0.035,0.117,-0.03（P 0.01）.Conclusions WBCC within a certain range associates with serum TG,TC and gender in Chongqing people,this WBCC will be a new object for lipoid metabolic diseases auxiliary diagnosis.

关 键 词：白细胞计数 甘油三酯 总胆固醇 脂类代谢性疾病 

分 类 号：R181.3[医药卫生—流行病学]