2型糖尿病神经病变患者血清IL-6、8-iso-PGF2α检测及意义  

Determination and Clinical Significance of Serum IL-6 and 8-iso-PGF2α in Patients with Diabetic Peripheral Neuropathy

作　　者：阮园[1] 谢晓竞[1] 马建华[1] 郭琳[1] 王敏[1] 

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)内分泌科,江苏南京210012

出　　处：《现代生物医学进展》2012年第16期3138-3140,共3页Progress in Modern Biomedicine

基　　金：江苏省自然基金项目(BK2010121)

摘　　要：目的:探讨2型糖尿病神经病变(DPN)患者血清IL-6、8-iso-PGF2α水平的变化及意义。方法:选择2型糖尿病患者伴神经病变的患者55例,单纯2型糖尿病不伴有神经病变的患者25例,另选25例体检健康者作为对照组。采用ELISA法分别测定各组血清IL-6、8-iso-PGF2α水平。结果:血清IL-6、8-iso-PGF2α水平在糖尿病组和糖尿病神经病变组均较对照组显著升高,差异具有统计学意义(P<0.01)。DN组8-iso-PGF2α较DM组显著升高,差异具有统计学意义(P<0.05);但IL-6在两组间差异无统计学意义(P>0.05)。结论:IL-6在糖尿病神经病变发病中的作用不能肯定。8-iso-PGF2α可能通过氧化应激作用参与糖尿病神经病变的发生发展。Objective： To investigate the levels and clinical significance of serum IL-6,8-iso-PGF2α in diabetic peripheral neuropathy patients.Methods： 25 DM（Diabetic Mellitus）patients,55 DN（Diabetic Neuropathy） patients,and 25 health people were chosen.Serum IL-6、in the 3 groups were detected through ELASA.Results： Serum IL-6 and 8-iso-PGF2α level were significantly higher in the DM and DN groups than the control group（P0.05）;Serum IL-6 level was higher in the DN group than in the DM group,but there was no significantly difference between two groups（P0.05）;Serum 8-iso-PGF2α level was significantly higher in the DN group than in DM group（P0.05）.Conclusion： This research showed the 8-iso-PGF2α had effect on the diabetes and diabetes nerve pathological changes.But it was not considered that IL-6 had effect on DN.

关 键 词：糖尿病 周围神经病变 白细胞介素-6 8-异前列腺素F2A 

分 类 号：R587.2[医药卫生—内分泌]