蟾酥抗肿瘤有效成分的作用研究  

Progress of Research on the Chemical Components of Venenum Bufonis and its Antitumor Effects

作　　者：毕琳琳[1] 缪珊[1] 王四旺[1] 

机构地区：[1]第四军医大学药学院天然药物学教研室,陕西西安710032

出　　处：《现代生物医学进展》2012年第16期3185-3187,共3页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金:脂蟾毒配基和人参皂苷Rg3联合抗肿瘤作用机制研究(2010JQ4019)

摘　　要：蟾酥(Venenum Bufonis)一词源自《本草衍义》,为我国名贵的传统中药。其含有多种化学成分,具有镇痛、强心、升压、局麻、抗炎和抗肿瘤等药理活性,临床应用广泛。蟾酥中抗肿瘤的有效成分为蟾毒配基类化合物,包括脂蟾毒配基、华蟾毒配基和蟾毒灵等。抗肿瘤活性主要包括诱导肿瘤细胞凋亡、抑制肿瘤细胞增殖、诱导肿瘤细胞分化等。近年来,有关蟾酥中活性成分在抗肿瘤方面的作用越来越成为国内外学者研究的热点。Venenum Bufonis,the name of which origin from the Canon of Chinese Materia Medica Ben Cao Yan Yi,is a rare and valuable traditional Chinese medicine.It is widely applied in clinic,for it contains many chemical components and has functions in analgesia,strong heart,boosting pressure,local anesthesia,anti-inflammatory and antitumor.The active antitumor component of venenum bufonis is bufogenin compound,including bufogenin,cinobufagin,bufalin and so on.The antitumor activity mainly includes inducing apoptosis of tumor cells,inhibiting the cell proliferation and inducing the cell differentiation.In recent years,the antitumor effects of venenum bufonis and its active components has become research focus at home and abroad.

关 键 词：蟾酥 化学成分 诱导凋亡 抑制增殖 诱导分化 细胞周期阻滞 

分 类 号：R285.5[医药卫生—中药学] R730.5[医药卫生—中医学]