砷中毒对体外实验细胞损伤的分子生物学机制研究进展  

The molecular biological effects of arsenic on cellular damage in vitro model study

作　　者：席淑华[1] 

机构地区：[1]中国医科大学公共卫生学院,辽宁沈阳110001

出　　处：《国外医学（医学地理分册）》2012年第2期73-75,共3页Foreign Medical Sciences：Section of Medgeography

基　　金：国家自然科学基金资助项目(No.81072244)

摘　　要：砷是确认的人类致癌物,但由于无机砷的致癌动物模型较难复制,使体外细胞实验成为砷致癌机制研究的必要手段。随着分子生物学技术的快速发展,体外细胞实验在揭示砷致细胞损伤的分子生物学作用、增强人们对砷致癌机制的认识上提供了有价值、可信的成果,对砷致癌机制研究的深入开展有重要的推动作用。然而,由于体外细胞实验自身的特点,以及砷在生物体内的甲基化代谢模式,使体外细胞实验在砷致癌机制的研究上也存在一定的局限性。Arsenic has been classified as a class I human carcinogen. Despite evidence in humans, it is difficult to replicate observed carcinogenesis of inorganic arsenic in animal models, hampering elucidation of the exact mechanism of arsenic related carcinogenicity. In vitro model is an important method to study the mechanism of arsenical-induced cellular damage. In vitro models have been developed and provided with valuable and credible results in the mechanisms of arsenic-induced cellular damage. However, there are still some limitations due to the characteristic of cells in vitro and methylation metabolism of arsenic.

关 键 词：砷 癌症 体外细胞实验 细胞损伤 

分 类 号：R181.3[医药卫生—流行病学]