初诊2型糖尿病患者胰腺脂肪沉积程度与胰岛素抵抗的关系  

The correlation between the degree of fat deposition in the pancreas and insulin resistance in newly diagnosed type 2 diabetes mellitus patients

作　　者：顾朋颖 康冬梅[1,2] 姚慧 曹东兴[1,3] 邓克学 王卫东[1,2] 

机构地区：[1]安徽医科大学附属省立医院 [2]安徽省立医院老年内分泌科,合肥230001 [3]安徽省立医院影像科,合肥230001

出　　处：《中国临床保健杂志》2012年第3期248-250,共3页Chinese Journal of Clinical Healthcare

基　　金：安徽省科技计划项目(10021403081);中医内分泌学学科开放基金(2011JY06)

摘　　要：目的研究初诊2型糖尿病(T2DM)患者胰腺脂肪沉积程度以及与胰岛素抵抗(IR)的关系。方法收集对照组(30例),T2DM非肥胖患者(20例),T2DM肥胖患者(30例),均接受上腹部CT检查,计算脾胰CT差值,评估胰腺脂肪沉积的程度。结果胰腺脂肪沉积程度在对照组[(4.29±3.39)Hu],T2DM患者[(8.56±6.15)Hu],T2DM肥胖患者[(8.10±5.82)Hu]内呈递增趋势(P<0.01),胰腺脂肪沉积是胰岛素抵抗指数(HOMA-IR)的独立相关因素(P<0.01)。结论胰腺脂肪沉积与IR相关,可能参与T2DM的发展。Objective To investigate the relationship between the fat deposition in the pancreas in newly diagnosed type 2 diabetes mellitus （T2DM） patients. Methods Fiftity newly diagnosed T2DM patients （ including twenty fat patients）,thirty healthy cases served as control were selected. All subjects had received upper abdominal CT scan and Hounsfield units （Hu） were measured. The differences between the mean values of spleen and pancreas were calculated and the extent of fat deposition in the pancreas were assessed. Results Compared to the control group（4.29 ± 3.39 Hu）, the degree of fat deposition in the pancreas in T2DM group （8.56 ± 6.15 Hu ） and fat T2DM （8.10 ±5.82 Hu） increased significantly （P 〈0.01 ）. The degree of fat deposition in the,pancreas was the independent relevant factors of insulin resistance index （ HOMA - IR） （ P 〈 0.01 ）. Conclusion The fat deposition in the pancreas may be involved in insulin resistance, and is closely related to T2DM.

关 键 词：糖尿病 2型 脂质贮积病/胰腺 胰岛素抵抗 体层摄影术 X线计算机 

分 类 号：R587.1[医药卫生—内分泌]