肿瘤抑制因子p53功能及其抗病毒作用研究进展  

Function of Tumor Suppressor p53 and its Role in Antiviral Immunity

作　　者：晏文君[1] 吴开宝[2] 马志永[1] 

机构地区：[1]中国农业科学院上海兽医研究所,上海200241 [2]南京农业大学动物医学院,南京210095

出　　处：《病毒学报》2012年第4期462-470,共9页Chinese Journal of Virology

基　　金：转基因生物新品种培育科技重大专项(2009ZX08010-022B);上海市基础研究重点项目(10JC1417300)

摘　　要：肿瘤抑制因子p53作为基因组的守护者,能通过细胞周期调控和促进细胞凋亡而阻止癌细胞及机体肿瘤的发生,p53还能参与DNA损伤修复、调节机体代谢及调节繁殖生育等功能。除此而外,近年来研究发现,p53能通过促进病毒感染的细胞凋亡而起到抗病毒作用以及p53受IFN的调控和p53作为转录调控因子还能直接转录激活IRF9、IRF5、ISG15和TLR3等抗病毒基因,从而确定了p53在抗病毒反应中起到重要作用。p53可能参与先天性免疫、获得性免疫及炎症反应而起到抗病毒的作用。Tumor suppressor p53, known as ＇the guardian of the genome~ , has the ability to prevent the emergence of transformed cells by the induction of cell cycle arrest and apoptosis. Otherwise, there were researches about the function of p53, such as NDA repair, regulating metabolism and maternal reproduction in recent years. Furthermore, there was a new function for p53 in antiviral apoptosis mentioned in the research, Integration of interferon-alpha/beta signaling to p53 responses in turnout suppression and antiviral defense. In order to define the antiviral function of p53, many target genes has been defined, such as IRF9, IRF5, ISG15 and TLR3. All of these implied there must be a complex mechanism for role of p53 in antiviral innate immunity, adaptive immunity and inflammation.

关 键 词：P53 抗病毒免疫 

分 类 号：R373.9[医药卫生—病原生物学] Q28[医药卫生—基础医学]