新疆3种植物提取物对二肽基肽酶Ⅳ活性的影响  被引量:4

Effect of dipeptidyl peptidase Ⅳ in 3 extracts from plants of Xinjiang

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作  者:杨珍珍[1] 王雪花 王烨[1] 毛新民[3] 韩雪[1] 易金阳[1] 王丽凤[4] 马晓丽[5] 李琳琳[1] 

机构地区:[1]新疆医科大学基础医学院药理学教研室,乌鲁木齐830011 [2]新疆伊犁新源县人民医院,新疆伊宁835800 [3]新疆医科大学中医学院,乌鲁木齐830011 [4]新疆医科大学基础医学院生理学教研室,乌鲁木齐830011 [5]新疆医科大学分析测试中心,乌鲁木齐830011

出  处:《新疆医科大学学报》2012年第6期721-724,共4页Journal of Xinjiang Medical University

基  金:国家自然科学基金(81060068)

摘  要:目的探讨葫芦巴、鹰嘴豆、石榴皮水提物对二肽基肽酶Ⅳ(DPP-4)体外活性的影响。方法采用DPP-4体外抑制模型,对新疆具有降糖作用的葫芦巴、鹰嘴豆、石榴皮3种植物水提取物进行筛选,选择抑二肽素A(IIe-pro-IIe)作为阳性对照药物,比较3种水提物的IC50差异。结果 IIe-pro-IIe的IC50为(0.01±0.01)mg/mL,葫芦巴水提物IC50为(0.03±0.01)mg/mL,石榴皮水提物IC50为(0.19±0.13)mg/mL,鹰嘴豆水提物IC50为(0.09±0.07)mg/mL。结论葫芦巴、石榴皮、鹰嘴豆的水提取物对DPP-4有一定程度的抑制作用。Objective To study the effect of dipeptidyl peptidase Ⅳ in extracts from Trigonella foenum-graecum L.Cicer arietinum L.Punica Granatum L.Methods The inhibitory effects of these 3 extracts to dipeptidyl peptidase Ⅳ activity were investigated by in vitro enzymatic method and IIe-Pro-IIe was used as positive reference substance.Comparison of 3 kinds of water extracts of IC50.Results IIe-pro-IIe IC50 was 0.01 mg/mL.Trigonella foenum-graecum L.water extraction IC50 was 0.03mg/mL,Punica Granatum L.water extraction IC50 was 0.19 mg/mL,Cicer arietinum L.water extraction IC50 was 0.09 mg/mL.Conclusion The 3 extracts of Xinjiang antidiabetic plant showed obviously inhibitory action against dipeptidyl peptidase Ⅳ activity.Trigonella,Pomegranate husk,Cicer arinum L.water extraction to dipeptidyl peptidase Ⅳ have different degrees of inhibition.

关 键 词:新疆降糖植物 提取物 二肽基肽酶Ⅳ抑制剂 

分 类 号:R285.5[医药卫生—中药学]

 

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