中重度慢性阻塞性肺疾病患者动态肺过度充气与运动能力的关系  

Correlation between Dynamic Hyperinflation and Exercise Capacity in Patients with Maderate to Severe Chronic Obstructive Pulmonary Disease

作　　者：黄旭斌[1] 谢灿茂[1] 严英硕[1] 

机构地区：[1]中山大学附属第一医院呼吸内科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2012年第3期383-386,共4页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省科技计划项目(2009B03081171);广州市科技局科技支撑项目(09A72060166)

摘　　要：【目的】探讨慢性阻塞性肺疾病(COPD)患者动态肺过度充气与运动能力的关系。【方法】对26例稳定期中重度COPD患者和12例健康人进行常规肺通气功能、弥散功能、肺容量和症状限制递增功率踏车心肺运动测试。在静息状态和运动过程中每隔1 min记录受试者潮式呼吸时流速容积曲线和深吸气量(IC)。【结果】COPD组在症状限制递增功率运动高峰时,IC(L)较静息状态下降(1.55±0.46 vs 2.17±0.50,P<0.001);运动高峰时ΔIC与摄氧量呈负相关(r=-0.422,P<0.05);运动高峰时IC与静息状态时IC呈负相关(r=-0.743,P<0.001),与运动高峰时潮气量(VT)呈负相关(r=-0.755,P<0.001)。【结论】动态肺过度充气可能是COPD患者在症状限制递增功率运动中运动能力下降的主要原因之一。[Objectives] To study the correlation between dynamic hyperinflation （DH） and exercise capacity in patients with chronic obstructive pulmonary disease （COPD）. [ Methods ] Routine lung ventilation function, diffusing function, lung volume and an incremental symptom-limited cycle ergometer exercise were tested in 26 stable COPD patients and 12 healthy controls. Flow-volume curve during tidal breathing and inspiratory capacity （IC） were detected every 1 min at rest and exercise. [Results] The IC （L） was significantly lower in COPD patients at peak exercise than at rest （1.55± 0.46 vs 2.17 ± 0.50,P 〈 0.001）. The AIC was negatively correlated with the peak oxygen consumption in COPD patients （r = -0.422, P 〈 0.05）. The peak IC was negatively correlated with both resting IC （r = -0.743, P 〈 0.001 ） and peak VT （r =-0.755, P 〈 0.001） in COPD patients. [Conclusions] DH might be one of the important factors for exercise intolerance in stable COPD patients during incremental symptom-limited cycle exercise.

关 键 词：肺疾病 慢性阻塞性 动态肺过度充气 运动能力 

分 类 号：R563[医药卫生—呼吸系统]