肾病综合征血脂代谢紊乱与血胆红素的关系研究  

Relationship between hyperlipidemia and serum bilirubin in nephrotic synodrome

作　　者：陈征[1] 王艳[1] 宋文琪[1] 徐樨巍[1] 

机构地区：[1]首都医科大学附属北京儿童医院检验科,100045

出　　处：《中国误诊学杂志》2012年第12期2815-2817,共3页Chinese Journal of Misdiagnostics

摘　　要：目的初探肾病综合征（NS）的高脂血症的发病机制与其血胆红素的关系。方法患儿禁食6h，空腹抽取静脉血检测总胆红素（TBIL）、直接胆红素（DBIL）、间接胆红素（IBIL）、甘油三酯（TG）、总胆固醇（CHO）、载脂蛋白B（APOB）、低密度脂蛋白（LDL—C）、载脂蛋白（a）（APOA）。结果NS组血清中TBIL、DBIL、IBIL、均低于正常对照组和肾炎组；NS组血清中TG、CHO、LDL、APOB、LDL—C、APOA均高于正常对照组和肾炎组（P〈O．01）；胆红素与TG、cH0采用相关性分析：TBIL与CHO、TG呈负相关（r=-0．55、P〈0．01；r=-0．41，P〈0．01）；DBIL与CHO、TG呈负相关（r=-0．61，P〈0．01；r=-0．45，P〈0．01）；IBIL与CH0、TG呈负相关（r=-0．52，P〈0．01；r=-0．36，P〈0．01）。结论胆红素水平与NS患者血脂的高低呈负相关，NS的血胆红素水平明显偏低。Objective To explore the relationship between hyperlipidemia and serum bilirubin level in nephrotic synodrome. Methods The whole subjects came from three groupes：One was nephritic syndrome. Two was chronic glomerulonephritis. The last was healthy controls. They named S group, T group, H group. S group was divided into normal and abnormal lipid parts. All items included TBIL, DBIL, IBIL, TG, CHO, APOB, LDL-C, APOA were de- tectd in vein samples which be obtained at 8：00 AM from the whole subject after stopping all foods and water for 6hours,in the meanwhile some urine bilirubine were detected too. Results Serum bilirubins in S group were lower obviously than T group and H group. Serum bilirubin in normal lipid part of S group was higher than those in abnor- mal lipid part. Conclusions The level of serum bilirubin is negative related with lipid in nephritic syndrome, and some lower bilirubin.

关 键 词：肾病综合征/代谢 脂类/血液 胆红素/血液 

分 类 号：R692[医药卫生—泌尿科学]