乙型肝炎患者血清前S_1抗原及其抗体检测的临床意义  

Expression of the preS_1 and Anti-preS_1 in the serum of Hepatitis B

作　　者：钟渊斌[1] 陈士彬[1] 徐宜宜[1] 

机构地区：[1]江西医学院一附院,南昌330006

出　　处：《江西医药》2000年第2期70-71,共2页Jiangxi Medical Journal

摘　　要：目的　探讨前S1抗原及其抗体在乙型肝炎患者血清中的表达及意义。方法　用ELISA法检测 2 2例急性乙肝 ,10 0例慢性乙肝 ,16例重型乙肝和 10例肝硬化。结果　HBsAg、前S1抗原阳性率分别为 90 .9%、87.5 % ,两者无显著性差异 ;急性乙肝病程中前S1抗体阳性率逐渐降低 ;慢性乙肝中转氨酶正常组和升高组 ,前S1抗体阳性率分别为 80 .0 %、33.0 %。结论　在急、慢性乙肝病毒感染中 ,无论是前S1抗原的出现还是抗体应答 ,都将导致肝脏病变的活动。Objective\ To study expression of the preS1 and Anti-preS1 in the serum of hepatitis B and its role.Methods\ The preS1 and Anti-preS1 was studied in 22 patients with acute hepatitis B,100 patients with postnecrotic liver cirrhosis by ELISA.Results\ There was no significantly difference between the positive rates of HBSAg,preS1.there were 90.0% and 87.5% respectively;In the acute hepatitis B,the positive rates of Anti-preS1 gradually decreased with infected time prolongatled;In the chronic hepatitis B with live function tests normal group and abnormal group.The positive rates of Anti-preS1 were 80.8% and 33.0% respectively.Conclusion\ Either preS1 appeared or the body immune responses induced by it lead to liver histopathologic activity.

关 键 词：乙型肝炎 前S1抗原 前S1抗体 血清诊断 

分 类 号：R512.620.4[医药卫生—内科学] R446.62[医药卫生—临床医学]