临床研究吸烟者血脂与冠状动脉病变严重程度的关系  

Relationship between severity of coronary arterial lesion and serum lipids in smokers

作　　者：王小萍[1] 周爱琴[1] 高木英[1] 

机构地区：[1]赣南医学院第一附属医院心内科,江西赣州341000

出　　处：《中国误诊学杂志》2012年第13期3139-3140,共2页Chinese Journal of Misdiagnostics

摘　　要：目的研究吸烟者血脂与冠状动脉病变程度的关系。方法对231例按受冠状动脉造影检查且资料大致匹配的吸烟患者（n=143）与非吸烟患者（n=88）进行回顾性研究，根据冠状动脉造影显示病变所累及血管的数量分为冠状动脉造影正常亚组和1支病变亚组、2支病变亚组及3支病变亚组，分析吸烟者与非吸烟者血脂异常与冠状动脉病变程度之间的关系。结果与吸烟者相比，非吸烟者的HDL-C水平更高（P〈0．05），冠脉病变程度更轻（P〈0．05或P〈0．01）。非吸烟者的各冠脉不同程度病变亚组与吸烟者各对应亚组比较，HDL-C和LDL-C／HDL-C水平更高，差异有统计学意义（P〈0．05或P〈0．01）。结论吸烟者中有更高的血脂异常发生率和更加严重的冠状动脉狭窄性病变。Objective To study the relationship between severity of coronary arterial lesion and serum lipids in smokers. Methods Totally 231 patients who underwent coronary angiography and were basically matched to the materials were studied retrospectively. All patients were divided into two groups which matched roughly by data： smoking group （n= 143）, non-smoking group （n= 88） and four subgroups aecording to the number of coronary artery damage： normal control subgroup, single vessel damage subgroup, double vessels damage subgroup and three vessels damage subgroup. The relationship between severity of coronary arterial lesion and serum lipids in smokers and non- smokers was analyzed. Results Compared with smokers, non-smokers had higher HDL C levels （ P〈 0. 05 ） and lighter degree of coronary lesions（P〈0.05 or P〈0.01 ）. Compared with the corresponding subgroups in smokers, HDL C and LDL C/HDL C levels were higher than subgroups in non-smokers and the differences were significant. Conclusions Smokers have a higher incidence of dyslipidemia and more severe coronary artery stenosis.

关 键 词：吸烟 脂类/血液 冠状动脉疾病 

分 类 号：R541.4[医药卫生—心血管疾病]