不明原因的复发性流产患者外周血T淋巴细胞功能的检测  

Detection of function of T Lymphocytes in peripheral blood of the women with URSA

作　　者：毛立群 张明[2] 徐大为[1] 

机构地区：[1]承德医学院微生物教研室,河北承德067000 [2]天津医科大学免疫学教研室,天津300070

出　　处：《河北医学》2000年第4期289-290,共2页Hebei Medicine

摘　　要：目的 :探讨不明原因的复发性流产 (URSA)与免疫因素的关系。方法 :采用形态学方法和 EL ISA双抗体夹心法分别对 30例 URSA患者及 30例健康妇女外周血中 T淋巴细胞转化率及血浆中可溶性 IL— 2受体 (SIL— 2 R)进行检测。结果 :URSA患者外周血中 T淋巴细胞转化率和血浆中SIL— 2 R水平均比正常对照组妇女高 (P<0 .0 5,P<0 .0 1)。结论 :URSA患者外周血中 T淋巴细胞被活化、细胞免疫功能增强 ,提示 T细胞介导的细胞免疫参与了 URSA的发生发展。Objective:[WT5BZ]To study the relationship between the occurrence of unexplained recurrent spontaneous abortion(URSA) and immune function.[WT5HZ]Methods:[WT5BZ][ST5BZ]T lymphocyte transformation test and level of soluble interleukin 2 receptor(SIL 2R) in peripheral blood from 30 cases of the patients with URSA and 30 cases of healthy women were detected by morphological method and enzymelinked immunosorbent assay sandwich assay,respectively.[WT5HZ]Results:[WT5BZ]Compared with the normal group,the percentage of T lymphoblasts and the level of SIl 2R in the women with URSA were increased(P<0.05,P<0.01).[WT5HZ]Conclusion:[WT5BZ]T lymphocytes of peripheral blood were activated and cellular immune function was enhanced in the women with URSA.The study suggested cellular immunity mediated by T cell might play a part in the pathogenesis of URSA. [WT5HZ]

关 键 词：复发性流产 SIL-2R T细胞 URSA 

分 类 号：R714.21[医药卫生—妇产科学]