高三尖杉酯碱局部应用的视网膜电图改变  

The ERG change of subconjunctival injection of homoharringtonine in rabbit

作　　者：顾宝文[1] 司马晶[1] 王抗美[1] 窦晓燕[1] 

机构地区：[1]深圳市红十字会医院,广东518035

出　　处：《深圳中西医结合杂志》2000年第2期68-69,共2页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨球结膜下注射高三尖杉酯碱对眼球的毒性作用方法在兔眼局部应用０．３ｍｇ／ｍｌ、０ ．４５ｍｇ／ｍｌ二种不同浓度剂量的高三尖杉酯碱，观察视网膜电图的变化结果在 ０ ．４５ｍｇ／ｍｌ浓度下，兔眼视网膜电图与对照组相比，ｂ波振幅发生异常结论高三尖杉酯碱在一定的剂量范围内，可安全的应用于临床。Objective To study the ocular toxicity of subconjunctival injection of homoharringtonine. Methods Two groups rabbits were received local using 0. 3mg/ml, 0. 45mg/ml homoharringtonine respectively, and observed the change of ERG. Results The abnormal b wave was observed when 0. 45mg/ml homoharring tonine was used comparing with the control group. Conclusion Homoharringtonine can be used safely within a certain dose extent to promoth the success rate of glaucoma filtering surgery within a certain dose extent.

关 键 词：高三尖杉酯碱 视网膜电图 眼毒性 

分 类 号：R979.1[医药卫生—药品] R774.1[医药卫生—药学]