眼镜蛇毒对成年大鼠海马CA3区Nestin表达的影响  

Effect of Naja naja atra venom on the expression of Nestin in hippocampus CA3 region of adult rats

作　　者：马同军[1] 丁见[1] 刘嵩[1] 熊克仁[1] 

机构地区：[1]皖南医学院解剖学教研室,安徽芜湖241002

出　　处：《蛇志》2012年第2期93-95,共3页Journal of Snake

基　　金：安徽省高等学校省级自然科学研究项目(项目编号:KJ2009B292Z)

摘　　要：目的探讨眼镜蛇毒对成年大鼠海马CA3区巢蛋白(Nestin)阳性细胞表达的影响。方法采用免疫组织化学方法,观察并比较Nestin阳性细胞在眼镜蛇毒组、生理盐水组、正常对照组大鼠海马CA3区的表达。结果眼镜蛇毒组大鼠海马CA3区Nestin阳性细胞较生理盐水组、正常对照组表达明显增强(P<0.01)。结论眼镜蛇毒对成年大鼠海马CA3区Nestin表达有上调作用。Objective To investigate the effects of Naja naja atra venom on the expression of Nestin in hippocampus CA3 region of adult rats.Methods The methods of immunohistochemistry technique were used to observe the different expression of Nestin positive cells in Naja naja atra venom group,saline group and control group.Results The number of Nestin positive cells in hippocampus CA3 region of Naja naja atra venom group were higher markedly than that of saline and control groups（P〈0.01）.Conclusion Naja naja atra venom could increase the expression of Nestin in hippocampus CA3 region of adult rats.

关 键 词：眼镜蛇毒 海马CA3区 NESTIN 大鼠 

分 类 号：R996.3[医药卫生—毒理学]