电针对老年性痴呆大鼠外侧隔核AChE阳性神经元表达影响  

Effects of electro-acupuncture therapy on AChE positive neurons in lateral septal nucleus of rats with Alzheimersdisease

作　　者：龚鑫[1] 黄锐[1] 熊克仁[1] 

机构地区：[1]皖南医学院解剖学教研室,安徽芜湖241002

出　　处：《蛇志》2012年第2期102-104,110,共4页Journal of Snake

基　　金：安徽省高等学校省级优秀青年人才基金项目(项目编号:2010SQRL173)

摘　　要：目的研究电针对老年性痴呆(AD)模型大鼠外侧隔核(LSN)乙酰胆碱酯酶(AChE)阳性神经元表达的影响。方法以D-半乳糖腹腔注射和Aβ1-40海马注射诱导形成老年性痴呆大鼠模型,电针"大椎"、"肾俞"、"太溪"三穴,以免疫组织化学法检测大鼠LSN中AChE阳性神经元的表达。结果与模型组相比,电针组AChE阳性神经元数量明显增多,具有显著统计学意义。结论电针可能通过增加大鼠LSN中AChE阳性神经元的表达,进而发挥抗老年性痴呆的作用。Objective To study the effects of electro-acupuncture therapy on AChE positive neurons in lateral septal nucleus of rats with Alzheimersdisease.Methods The AD model was established by abdominal injecting the D-galactose first and then hippocampus injecting β-amyloid 1-40.Then ＂Dazhui＂ Point and ＂Shenshu＂ Point and ＂Taixi＂ Point were electro-acupunctured,the expressions of AChE positive neurons in lateral septal nucleus were detected by using immunohistochemistry.Results In comparison with control group,AChE positive neurons were increased obviously in electro-acupuncture group.Conclusion electro-acupuncture may be by increasing the expression of AChE positive neurons in lateral septal nucleus,and thus play the role of anti-senile dementia.

关 键 词：电针 老年性痴呆 乙酰胆碱酯酶 外侧隔核 

分 类 号：R245.311[医药卫生—针灸推拿学] R749.16[医药卫生—中医临床基础]