原因不明性习惯性流产患者的B淋巴细胞免疫治疗  

Immunotherapy by B-lymphocytes in Patients with Unexplained Habitual Abortion

作　　者：朱国平[1] 周莹[1] 宁波[2] 孙苒 方菲[3] 

机构地区：[1]广州市东山区人民医院妇产科,510080 [2]中山医科大学免疫教研室 [3]广州市东山区人民医院检验科,510080

出　　处：《中华妇产科杂志》2000年第4期212-213,共2页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　探讨安全、有效的对人类白细胞抗原 (HLA)共有抗原增大的原因不明性习惯性流产 (UHA)患者的免疫治疗方法。方法　采用丈夫静脉血的B淋巴细胞使 2 4例UHA的患者免疫化。结果　 2 4例UHA患者中有 2 2例HLA共有抗原增大。UHA患者中免疫治疗前抗父体的淋巴细胞毒性抗体 (APCA)阳性率是 8% (2 / 2 4) ,免疫治疗 3个月后APCA阳性率是 75 % (18/ 2 4) ,2 8例对照者的APCA阳性率是 86 % (2 4/ 2 8) ;UHA患者治疗前的APCA阳性率与对照组比较 ,差异有显著性 (P <0 .0 5 ) ;UHA患者治疗前后APCA阳性率比较 ,差异有显著性 (P <0 .0 5 )。UHA患者免疫治疗后妊娠率为 80 % (16 / 2 0 )。免疫治疗后出生的新生儿无低体重儿及畸形儿。结论　丈夫B淋巴细胞具有使妻子免疫化及提高妊娠成功率的作用 ,也具有降低不良反应的可能。Objective To investigate the safety and efficacy of immunotherapy in patients with unexplained habitual abortion(UHA) with increased human leukocyte antigen (HLA) mutual antigen. Methods Twenty four UHA women were immunized by their husband′s B lymphocytes for 3 months. Results Twenty two of them had increased HLA mutual antigen. The their anti paternal lymphocytotoxic antitody (APCA) positive rate was 8% before immunization, significantly lower than that of the control group (86%). After immunization, the APCA positive rate increased significantly to 75%, 20 cases achieved pregnancy and 16 deliverd normal newborns. Conclusion Immunotherapy by husband′s B lymphocytes is effective in UHA with increased HLA mutual antigen,and may have less adverse effect.

关 键 词：流产 习惯性 B淋巴细胞 免疫治疗 

分 类 号：R714.21[医药卫生—妇产科学]