围绝经期妇女应用7-甲基异炔诺酮进行激素替代治疗顺应性调查  

Evaluation on the Compliance of Livial Therapy in Peri and Postmenopausal Women

作　　者：白文佩[1] 杨欣[1] 王炎[2] 黄淑媛 郑淑蓉[1] 

机构地区：[1]北京医科大学第一医院妇产科,100034 [2]桂林医学院附属医院妇产科

出　　处：《中华妇产科杂志》2000年第4期219-221,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　探讨围绝经期妇女应用 7 甲基异炔诺酮进行激素替代治疗的顺应性。方法　调查 134例围绝经期处方 7 甲基异炔诺酮者的用药状况 ,包括医嘱遵从性、中断比例及其原因以及体重改变、阴道出血、胃肠道反应等副作用。 134例妇女平均 5 5 .2岁 ,绝经 6 .7年 ,97.0 %因围绝经期症状就诊。结果　 90 .3%接受处方即开始治疗 ,治疗时间≤ 1年者 5 3例 ,治疗 >1年、≤ 3年者 5 5例 ,>3年、≤ 5年者 10例 ,>5年者 4例。 41.0 %的妇女在首次用药 (0 .7± 0 .8)年后中断 ,其中 14.8%完全中断 ,2 6 .2 %在 (0 .3± 0 .2 )年后因症状复发重新用药。中断用药的主要原因是担心诱发癌症。用药前后体重指数无明显变化 ,用药期间阴道出血比例为 5 .6 % ,乳腺胀痛、下肢水肿、胃肠道症状发生率分别为 19.7%、8.2 %和 9.0 % ,多发生在最初用药半年内。结论　围绝经期妇女对 7 甲基异炔诺酮的医嘱遵从性较好 ,但仍有一定的中断比例。Objective To evaluate the compliance of livial therapy in peri and postmenopausal women. Methods One hundred thirty four peri and postmenopausal women advised to take Livial were studied for persistency,efficacy and side effect of treatment. Results The mean age is 55.2 years old and post menopausal period is averaged 6.7 years. Their chief complaints were mainly climacteric symptoms(97.0%). Ninety percent of women took livial after prescription. 41.0% of women ceased the therapy after (0.7±0.8) years of treatment, while 26.2% of them restored after (0.3±0.2) years due to recurrence of symptoms. The major reason of cease was fear of cancer. The climacteric symptoms were well relieved while body mass index remained unchanged. The occurrence of vaginal bleeding, breast tenderness, edema and gastrointestinal symptoms was 5.6%, 19.7%, 8.2% and 9.0% respectively. The side effect was dose dependent. Conclusion Postmenopausal women had well compliance to Livial despite of mild side effects and ceasing ratio.

关 键 词：雌激素替代治疗 异炔诺酮 绝经后期 

分 类 号：R711.5[医药卫生—妇产科学]