阿德福韦酯不规范停药47例临床观察  

Study on the consequence of 47 patients with hepatitis B stopping adefovir dipivoxil without doctor′s advice

作　　者：杨根领 

机构地区：[1]济宁市传染病医院三病区,山东省济宁272131

出　　处：《中国基层医药》2012年第12期1775-1776,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨阿德福韦酯不规范停药的危害性。方法 回顾性分析47例慢性乙型肝炎患者盲目停用阿德福韦酯后病情变化及转归。结果 擅自停药导致病情反复者,1个月内8例（17.0%）均为HBVDNA未阴转者,3个月内34例（72.3）%,6个月内41例（87.2%）。其中4例肝硬化患者死亡,33例重新服用阿德福韦酯,10例换用恩替卡韦,其后逐渐好转。结论 盲目停用阿德福韦酯会导致慢乙肝患者HBVDNA含量升高,病情恶化。Objective To investigate the damage of stopping Adefovir without doctor′s advice.Methods Clinical manifestations,prognosis of 47 cases with hepatitis B stop Adefovir without doctor′s advice were analyzed retrospectively.Results Among the cases stopping adefovir without doctor′s advice to take a change for the worse,8 cases HBVDNA positive within a month,34 cases in 3 months,41 cases in 6 months.And 4 patients with liver cirrhosis died,33 cases took Adefovir again,10 cases took entecavir,and gradually got well.Conclusion Stopping Adefovir dipivoxil without doctor′s advice may be lead to elevated HBVDNA,change for the worse.

关 键 词：肝炎 乙型 慢性 阿德福韦酯 患者拒绝治疗 

分 类 号：R512.62[医药卫生—内科学]