甲氨蝶呤联合米非司酮保守治疗与腹腔镜手术治疗异位妊娠的疗效比较  

The efficacy comparison of methotrexate combined with mifepristone and laparoscopic surgery for treating ectopic pregnancy

作　　者：蒋秋丽 陈钢[1] 

机构地区：[1]汉中市中心医院妇科,陕西省汉中723000

出　　处：《中国基层医药》2012年第12期1781-1782,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 比较甲氨蝶呤联合米非司酮保守治疗与腹腔镜手术治疗异位妊娠的疗效。方法 将85例异位妊娠患者,按自愿原则选择甲氨蝶呤联合米非司酮药物保守治疗的41例患者作为对照组,选择接受腹腔镜手术治疗的44例患者作为观察组。观察比较两组患者的临床疗效、治疗7 d后血人绒毛膜促性腺激素测定（β-HCG）值的变化及恢复正常的时间。结果 治疗后,观察组患者的治愈率为100%,明显高于对照组的90%（P〈0.05）;观察组患者的血β-HCG值降低较对照组快,恢复正常的时间短（P〈0.05）。结论 腹腔镜手术治疗与甲氨蝶呤联合米非司酮药物保守治疗均能有效治疗异位妊娠,但腹腔镜手术治疗的临床疗效更佳,恢复快,能较彻底治愈患者。Objective To investigate the efficacy of methotrexate combined with mifepristone and laparoscopic surgery for treating ectopic pregnancy.Methods 85 patients with ectopic pregnancy were selected.41 cases treated with methotrexate and mifepristone were considered as the control group,while 44 cases with laparoscopic surgery were considered as the observation group on the voluntary basis.The clinical efficacy,serum β-HCG value and recovery time after 7d were compared between the two groups.Results After the treatment,the cure rate in the observation group was 100% which was significantly higher than 90%of the control group（P〈0.05）,the serum β-HCG value of the observation group was lower and the restoration normal time was shorter than the control group（P〈0.05）.Conclusions Laparoscopic surgery and conservative treatment of methotrexate combined with mifepristone are effective in the treatment of ectopic pregnancy.However,the clinical efficacy of the laparoscopic surgery is better and it has rapid recovery time,and it can completely cure the patients.

关 键 词：妊娠 异位 甲氨蝶呤 米非司酮 腹腔镜检查 

分 类 号：R714.22[医药卫生—妇产科学]