Granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells for the treatment of ischemic stroke  

作　　者：Xingjian Lin Yingdong Zhang Weiguo Liu Jingde Dong Jie Lu Qing Di Jingping Shi 

机构地区：[1]Nanjing Medical University, Affiliated Nanjing Brain Hospital, Department of Neurology, Nanjing 210029, Jiangsu Province, China [2]Nanjing Medical University, Affiliated Nanjing First Hospital, Department of Neurology, Nanjing 210029, Jiangsu Province, China

出　　处：《Neural Regeneration Research》2012年第16期1220-1227,共8页中国神经再生研究（英文版）

基　　金：supported by a grant from "135 Project" Foundation of the Public Health Department of Jiangsu Province,China;Nanjing Medical Science and Technique Development Foundation

摘　　要：Adult, male, Sprague-Dawley rats were injected with granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells （GM-CSF-BMSCs） into the ischemic boundary zone at 24 hours after onset of middle cerebral artery occlusion. Results showed reduced infarct volume, decreased number of apoptotic cells, improved neurological functions, increased angiogenic factor expression, and increased vascular density in the ischemic boundary zone in rats that underwent GM-CSF-BMSCs transplantation compared with the BMSCs group. Experimental findings suggested that GM-CSF-BMSCs could serve as a potential therapeutic strategy for ischemic stroke and are superior to BMSCs alone.Adult, male, Sprague-Dawley rats were injected with granulocyte-macrophage colony-stimulating factor-transfected bone marrow stromal cells （GM-CSF-BMSCs） into the ischemic boundary zone at 24 hours after onset of middle cerebral artery occlusion. Results showed reduced infarct volume, decreased number of apoptotic cells, improved neurological functions, increased angiogenic factor expression, and increased vascular density in the ischemic boundary zone in rats that underwent GM-CSF-BMSCs transplantation compared with the BMSCs group. Experimental findings suggested that GM-CSF-BMSCs could serve as a potential therapeutic strategy for ischemic stroke and are superior to BMSCs alone.

关 键 词：bone marrow stromal cells granulocyte-macrophage colony-stimulating factor gene transfection ischemic stroke TRANSPLANTATION stem cells neural regeneration 

分 类 号：Q786[生物学—分子生物学] Q813.1