缺失型血管紧张素转换酶基因与心肌梗死患者血浆载脂蛋白E水平的关系  

Relation between plasma apolipoprotein E and deletion polymorphism of the angiotensin-converting enzyme gene in patients with old myocardial infarction

作　　者：李刚[1] 陈运贞[2] 曾昭淳[3] 柳青[2] 黄维嘉[2] 姚珍微 兰雁飞[2] 许炜[2] 凌红 邓国兰[2] 

机构地区：[1]重庆医科大学附属第二医院心内科 [2]重庆医科大学附属第一医院心内科,重庆400016 [3]重庆医科大学基础医学院基础生化教研室

出　　处：《临床心血管病杂志》2000年第4期161-162,共2页Journal of Clinical Cardiology

摘　　要：目的 :探讨缺失型血管紧张素转换酶 (ACE)基因与心肌梗死患者血浆载脂蛋白 E(apo E)浓度间的关系。方法 :用免疫比浊法测定 5 5例陈旧性心肌梗死 (OMI)患者及 47例对照者血浆 apo E浓度。用 PCR法检测ACE基因缺失 (D) /插入 (I)多态性。结果 :OMI患者血浆 apo E浓度为 (5 2 .1± 14.6 ) m g/ L ,显著高于对照组(41.2± 17.2 ) mg/ L (P <0 .0 5 )。 OMI组 ACE DD(5 1.2± 14.7) m g/ L、DI(5 4.7± 12 .1) mg/ L、II(5 9.0± 2 6 .0 )m g/ L基因型间血浆 apo E水平无显著性差异 (P >0 .0 5 )。 ACE DD基因型频率及 D等位基因频率与对照组比较无显著性差异 (P>0 .0 5 )。结论 :缺失型 ACE基因可能与 OMI患者血浆 apoObjective:To explore the relation between plasma apolipoprotein E (apo E) and deletion polymorphism of the angiotensinconverting, enzyme (ACE) gene in patients with old myocardial infarction (OMI).Method:The plasma apo E level was detected by immunoturbidimetric assay;the deletion (D)/Insertion (I) polymorphism of the ACE gene was determined by polymerase chain reaction (PCR) in 55 patients with OMI and in 47 controls.Result:The plasma apo E level 〔( 52.1 ± 14.6 ) mg/L〕 was higher statistically (P< 0.05 ) in patients with OMI than in controls〔 ( 41.2 ± 17.2 ) mg/L〕.There were not significant differences (P> 0.05 ) of plasma apo E level among ACE DD 〔( 51.2 ± 14.7 ) mg/L〕,DI〔( 54.7 ± 12.1 ) mg/L 〕and II〔 ( 59.0 ± 26.0 ) mg/L〕 gene types in the OMI group.Conclusion:The relation between plasma apo E and deletion polymorphism of ACE gene was not found in patients with OMI.

关 键 词：载脂蛋白E 血管紧张素转移酶 心肌梗塞 

分 类 号：R542.220.2[医药卫生—心血管疾病]