碱性成纤维细胞生长因子预防球囊成形血管再狭窄  

Experimental study of the preventive effects of basic fibroblast growth factor on vascular restenosis after balloon angioplasty

作　　者：乔延国[1] 刘辉[2] 王发强[1] 卢柏桦 

机构地区：[1]北京武警总医院心内科,北京100039 [2]武警8640部队医院内科

出　　处：《临床心血管病杂志》2000年第4期180-182,共3页Journal of Clinical Cardiology

摘　　要：目的 :探讨实验性兔髂动脉粥样硬化狭窄模型于血管成形后 ,给予碱性成纤维细胞生长因子 (b FGF) ,对改善血管内皮功能及对再狭窄的预防作用。方法 :建立髂动脉狭窄模型兔 6 0只 ,2 0只用于成形前 (10只 )和成形后即刻 (10只 )管腔面积的组织学分析 ,余 40只随机分成 b FGF组和对照组 ,于血管成形后 4周两组兔均处死 ,行体外血管反应性测试和管腔面积的组织学分析。结果 :由乙酰胆碱诱导的内皮依赖性最大舒张反应 (Emax)b FGF组 [(41± 8) % ]大于对照组 [(12± 9) % ],P <0 .0 5 ;由硝普钠 (SNP)诱导的内皮非依赖性血管 Emax b FGF组 [(88± 7) % ]大于对照组 [(6 6± 5 ) % ],P <0 .0 5 ;血管成形后 4周对照组腔面积 [(0 .5 4± 0 .2 6 ) mm2 ]小于b FGF组 [(1.0 8± 0 .32 ) mm2 ],P <0 .0 5 ,比成形后即刻 [(1.2 0± 0 .2 8) mm2 ]狭窄 5 5 %。结论 :实验性髂动脉粥样硬化狭窄模型兔于血管成形后给予 b FGF,在促进内皮依赖性及非依赖性血管舒张功能恢复的同时 。Objective:To investigate whether chronic administration of basic fibroblast growth factor (bFGF) after angioplasty in rabbits model with atherosclerotic iliac stenosis can restore normal physiological responses to endothelium dependent and independent agonists,and the effect of bFGF on the formation of restenosis (RS).Method:60 Japanese white rabbits with atherosclerotic stenosis of right iliac arteries were used.20 of them underwent histological study of lumen areas before (10 rabbits) and immediately after (10 rabbits) angioplasty.20 rabbits received intravenous administration of bFGF.20 rabbits receiving vehicle injection served as controls.Animal in both groups were then killed on 28 days after operation for analysis of in vitro vasoreactivity and morphometric assessment of histological crosssection areas.Result:Showed the maximal endotheliumdependent Achinduced relaxation of the bFGFtreated animals 〔Emax (41±8)%〕 was significantly greater than that of the control group 〔Emax (12±9)%,P< 0.05 〕.The maximal endotheliumindependent response of the bFGFtreated group to SNP 〔Emax,(88±7)%〕 was greater than that of the control group 〔Emax (66±5)%,P< 0.05 〕.Lumen area 4 weeks after angioplasty in bFGF group 〔( 1.08 ± 0.32 ) mm2〕 was greater than that in control group 〔( 0.54 ± 0.26 )mm2,P< 0.05 〕.Lumen area decreased by 55% from immediately after angioplasty to 4 weeks after angioplasty.Conclusion:The results suggested that the administration of bFGF could not only restore endotheliumdependent andindependent relaxation but also prevent RS in rabbits that had undergone angioplasty.

关 键 词：碱性成纤维细胞生长因子 血管成形术 血管再狭窄 

分 类 号：R654.206[医药卫生—外科学] R543.01[医药卫生—临床医学]