重组人生长激素治疗兔桡骨小段缺损  

Recombinant human growth hormone for treatment of radial bone defects in rabbits

作　　者：王一民[1] 江正康[1] 林奇生[1] 马树强[1] 巫伟东[1] 李中檀[1] 黄醒忠[1] 

机构地区：[1]广东医学院附属深圳福田医院创伤骨科,广东省深圳市518033

出　　处：《中国组织工程研究》2012年第24期4387-4392,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:生长激素可直接作用于外周组织如软骨、骨及脂肪组织等,对骨折应有促愈合作用。目的:观察重组人生长激素对兔桡骨小段骨缺损的治疗作用。方法:10只成年新西兰大白兔制备双前臂骨缺损模型,所有模型兔随机分成治疗组和对照组。治疗组造模后第1天开始皮下注射重组人生长激素,连续14d;对照组同样方法注射等量生理盐水。结果与结论:治疗组骨痂生长及细胞形态分化与钙质沉着均比对照组快;血糖治疗期间略升高,治疗结束后迅速恢复正常。说明重组人生长激素有促进骨痂生长、加快骨折愈合作用,表明该药可用于骨折及小范围骨缺损的治疗,未见明显不良反应。BACKGROUND： Growth hormone may act directly on the peripheral tissues such as cartilage, bone, and adipose tissue etc., and it can promote fracture healing. OBJECTIVE： To observe the therapeutic effects of recombinant human growth hormone on small-segment radial bone defects in rabbits. METHODS： Twenty radial bone defect models were made in 10 New Zealand rabbit forelimbs and were randomly divided into treatment and control groups. The treatment group was subcutaneously injected recombinant human growth hormone after the operation for 2 weeks; in the same method and duration, the control group was injected the same amount of isotonic saline as a placebo. RESULTS AND CONCLUSION： The treatment group was obviously superior to the control group in callus growth, differentiation of cell morphology and calcinosis. Blood glucose level of the treatment group was slightly higher than that of the controlled group during the treatment, and recovered when the treatment was finished. These findings indicate that recombinant human growth hormone has an effective treatment effect on fractures as well as bone defects and no side effect is observed.

关 键 词：重组人生长激素 桡骨骨缺损 兔模型 骨痂 血糖 

分 类 号：R318[医药卫生—生物医学工程]