ε-己内酯/D,L-丙交酯共聚物的非等温结晶动力学研究  

Non-isothermal crystallization kinetics of degradable copolymer based on epsilon-caprolactone and D,L-lactide

作　　者：杨立群 杨丹 李建新 关艳敏 李淼 

机构地区：[1]辽宁省计划生育科学研究院,辽宁省沈阳市110031

出　　处：《中国组织工程研究》2012年第25期4654-4658,共5页Chinese Journal of Tissue Engineering Research

基　　金：辽宁省自然科学基金资助项目(20092017)~~

摘　　要：背景:ε-己内酯/D,L-丙交酯共聚物因具有良好的力学性能、降解性能以及生物相容性而受到广泛研究,但对其非等温结晶动力学研究相对较少。目的:了解ε-己内酯/D,L-丙交酯共聚物的非等温结晶动力学性能。方法:以实验室自制的ε-己内酯:D,L-丙交酯共聚物90:10为观察对象,采用示差扫描量热仪对其进行非等温测试,观察其结晶行为。结果与结论:随着降温速率R的增加,PCDLA的结晶温度向低温方向移动,且Avrami指数均>3,以均相成核的三维球晶方式生长;Jeziorny法和莫志深法研究结果基本一致。BACKGROUND： Copolymers of ε-caprolactone and D, L-lactide （PCDLA） has been studied intensely for their good mechanical properties, biodegradability and biocompatibility. However, the study on non-isothermal crystallization kinetics of PCDLA has attracted less attention. OBJECTIVE： To investigate the non-isothermal crystallization kinetics of PCDLA. METHODS： PCDLA with a CL/DLLA molar ratio of 90：10 was prepared by ring-opening polymerization and differential scanning calorimetry was employed to study the non-isothermal crystallization kinetics of PCDLA. The kinetics parameters were analyzed by Avrami, Jeziorny and Mo methods. RESULTS AND CONCLUSION： The crystallization peak temperatures of PCDLA decreased with increasing cooling rate In the process of non-isothermal crystallization, the value of Avrami index was greater than 3 for PCDLA, which demonstrates a three-dimensional spherulitic growth on homogeneous nuclei. The Jeziorny method of the corrected Avrami theories and Mo method can describe non-isothermal crystallization kinetics of PCDLA very well.

关 键 词：非等温结晶动力学 Ε-己内酯 D L-丙交酯 共聚物 生物降解材料 生物材料 

分 类 号：R318[医药卫生—生物医学工程]