丙烯海松酸基双硫脲类化合物的合成与表征  

Synthesis and characterization of acrylpimaric acid-based dithioureas

作　　者：赖刚[1] 何熙璞[1] 李芳耀[1,2] 段文贵[1] 李宇彬[1] 韦有杰[1] 

机构地区：[1]广西大学化学化工学院,广西南宁530004 [2]桂林医学院药学院,广西桂林541004

出　　处：《广西大学学报（自然科学版）》2012年第3期489-494,共6页Journal of Guangxi University（Natural Science Edition）

基　　金：国家自然科学基金资助项目(31060100);广西自然科学基金重点资助项目(2010GXNSFD013013)

摘　　要：为了寻找具有生物活性的新的先导化合物以及为松香的深加工提供新的途径,以松香和丙烯酸为原料,经Diels-Alder(D-A)加成反应制备丙烯海松酸。将丙烯海松酸转化为双酰氯,再与硫氰酸钾反应,制得丙烯海松酸基双异硫氰酸酯,最后与苯胺衍生物发生反应,合成得到10个新型丙烯海松酸基双硫脲类化合物。采用IR、MS、1H NMR和13C NMR对所合成的目标化合物进行了结构表征。In order to search for novel lead compounds with bioactivity and provide a new pathway for the deep processing of rosin, acrylpimaric acid was prepared by Diels-Alder addition reaction u- sing rosin and acrylic acid as starting materials, and converted into its dichloride. Then, acrylpimar- ic acid diisothiocyanates were prepared by the reaction of dichloride with potassium thioeyanate, fol- lowed by the reaction of acrylpimaric acid diisothiocyanates with phenyl amines to form ten novel acrylpimaric acid-based dithioureas. The target compounds were characterized by means of IR, MS, ^1H NMR and ^13C NMR.

关 键 词：丙烯海松酸 双硫脲 合成 表征 

分 类 号：O621.1[理学—有机化学]