金银花化学成分的研究  

Chemical constituents of Lonicera japonica

作　　者：崔春雨[1] 刘志平[1] 周敏[1] 苏德辉[1] 唐新宗[1] 韦万兴[1] 

机构地区：[1]广西大学化学化工学院,广西南宁530004

出　　处：《广西大学学报（自然科学版）》2012年第3期530-533,共4页Journal of Guangxi University（Natural Science Edition）

基　　金：国家自然科学基金资助项目(81060261);广西自然科学基金项目重点项目(2011GXNSFD018016)

摘　　要：为了研究用简单的方法从金银花中分离化合物,采用选择性萃取法从金银花浸膏的乙酸乙酯萃取部位分离得到化合物Ⅰ,然后经过硅胶柱层析分离得到化合物Ⅱ、Ⅲ、Ⅳ。通过理化方法和MS、IR、H-NMR、C-NMR等谱学技术对分离得到的4种化合物进行结构鉴定,分别鉴定为3',4',5',5,7-五甲氧基黄酮(Ⅰ)、木犀草素(Ⅱ)、槲皮素(Ⅲ)、绿原酸(Ⅳ)。其中化合物Ⅰ为首次从该属植物中发现,并且是经过选择性萃取分离得到的。该方法简单快捷,较之柱色谱法有较大优势。To find a simple way to isolate the constituents of Lonicera japonica, selective extraction methods were employed. Compound I was isolated from the ethyl acetate extract of Lonicera japoni- ca by the selective extraction, then compounds Ⅱ ,Ⅲ and Ⅳ were isolated from the remaining ethyl acetate extract by silica gel column chromatography successively. Their structures were elucidated by means of physico-chemical properties, MS, IR and NMR evidences as 3＇ ,4＇ ,5＇ ,5,7-Pentamethoxy flavone （ Ⅰ ） , luteolin （ Ⅱ ） , quercetin （ Ⅲ ） and chlorogenic acid （ Ⅳ ） , respectively. Compound Ⅰ was found in this genus for the first time, and it was isolated with the selective extraction which is advantagous over the traditional column chromatograph.

关 键 词：金银花 化学成分 黄酮类 3' 4' 5' 5 7-五甲氧基黄酮 

分 类 号：R284[医药卫生—中药学]