国产相对低分子质量肝素在血液透析中的抗凝疗效  

Effect of homemade low molecular weight heparin on hemodialysis

作　　者：罗惠民[1] 张金黎[1] 马宝栋[1] 马玉林[1] 杨燕[1] 陈慧 李明[1] 

机构地区：[1]云南省第一人民医院,肾内科昆明650032

出　　处：《中国临床药学杂志》2000年第2期67-69,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的 :观察应用国产相对低分子质量肝素 (L MWH)在血液透析中的抗凝疗效 ,并且与速避凝、肝素钙进行比较。方法 :5例长期维持性血液透析患者通过自身对照 ,按顺序分别给予国产 L MWH、速避凝、肝素钙各 6次作为血液透析抗凝剂 ,观察透析器凝血 ,穿刺点压迫止血时间 ,透析器对血肌酐、尿素氮清除率 ,监测白陶土部分凝血活酶时间 (KPTT)、凝血酶时间(TT)及血常规变化。结果 :国产 L MWH、速避凝对 KPTT、TT影响不明显 ,而肝素钙使 KPTT、TT显著延长 ,3种抗凝剂均对透析器无凝血 ,透析器对血肌酐、尿素氮清除效率相似。结论 :国产 L MWH与速避凝效果相似 ,能保证透析效果 。AIM: To study the anticoagulant effectiveness of low molecular weight heparin (LMWH) in hemodialysis and to compare with fraxiparine or heparin calcium. METHODS: LMWH, fraxiparine or heparin calcium were given respectively in 5 patients on maintenance hemodialysis for 6 consecutive times. Coagulation in dialyzer , urea and creatinine clearance of dialyzer, hemostatic time of point of puncture and changes in kaolin partial thromboplastin time (KPTT) and thrombin time (TT) were observed. RESULTS: KPTT and TT were significantly shorter during LMWH or fraxiparine than that of heparin calcuim. There were no differences of coagulation in dialyzer, effective urea and creatinine of clearances of dialyzer. CONCLUSION: The anticoagulative efficiency is similar between LMWH and fraxiparine.

关 键 词：相对低分子质量肝素 血液透析 抗凝疗效 

分 类 号：R459.5[医药卫生—治疗学] R973.2[医药卫生—临床医学]