内镜下电灼术治疗溃疡型膀胱疼痛综合征/间质性膀胱炎患者临床研究  

The efficacy and safety of endoscopic fulguration for classic ulcerative type bladder pain syndrome/interstitial cystitis

作　　者：朱绪辉[1] 符骏[2] 杜鹏[1] 善辉[1] 李涛[1] 张鹏[1] 杨勇[1] 

机构地区：[1]首都医科大学附属北京朝阳医院(西区)泌尿外科,北京100043 [2]北京京煤集团总医院泌尿外科

出　　处：《临床泌尿外科杂志》2012年第7期540-542,545,共4页Journal of Clinical Urology

摘　　要：目的:探讨内镜下电灼术治疗溃疡型膀胱疼痛综合征/间质性膀胱炎患者(bladder pain syndrome/interstitial cystitis;BPS/IC)的临床有效性和安全性。方法:所有患者在膀胱镜检+水扩张后,病理回报明确为非特异性炎症者,排除恶性肿瘤疾病,明确为BPS/IC诊断后,分为溃疡型和非溃疡型。随机选取32例溃疡型BPS/IC患者行膀胱溃疡内镜下电灼术治疗。观察手术治疗前后(术后随访1、3、6个月)病情变化如:临床症状情况(每日排尿次数、最大排尿容量、膀胱区疼痛程度评分)和O’Leary-Sant间质性膀胱炎问卷表评分及生活质量评分(QOL)情况。结果:32例溃疡型BPS/IC患者,男5例,女27例,年龄36～60岁,平均(47.0±6.2)岁;病程1～5年,平均(3.5±1.2)年。本组患者症状改善总有效率78.1%(25/32),其中完全缓解率为53.1%(17/32),部分缓解率为25%(8/32),治疗无效率为21.9%(7/32)。手术治疗后患者平均每日排尿次数、每次排尿量、疼痛程度、O’Leary-Sant评分、生活质量评分与治疗前相比均存在显著改善(P<0.01)。结论:内镜下电灼术治疗溃疡型BPS/IC患者能够有效缓解临床症状和改善生活质量。Objective： To evaluate the efficacy and safety of endoscopic fulguration for classic ulcerative type bladder pain syndrome/interstitial cystitis（BPS/IC）. Method：Thirty-two patients with classic ulcerative type BPS/ IC were involved in this trial. Clinical symptoms（micturition frequency per day, maximal micturition volume and cystodynia degree score）,O＇Leary-Sant IC symptom and problem index,and quality of life score were assessed at baseline and then again after operation treatment. Side effects was recorded. Result：There were 5 male and 27 female patients in our study, the average age was 47±6.2 （range from 36 to 60）, the average duration of symptoms was 3.5 ± 1.2 years（from 1 to 5 years）before treatment. The response rate was 78.1% （25/32）, Overall satisfaction was 53.1% （ 17/32）, Partial satisfaction was 25 % （ 8/32）, None response rate was 21.9 % （ 7/32 ）. For all pa- tients, the mean voiding times, voiding volume per time, cystodynia degree score, average O＇ Leary-Sant score, and quality of life score pre-treatment were statistically improved post-treatment respectively, P〈0.01. Conclusion： Treating classic ulcerative type BPS/IC patients with endoscopic fulguration can effectively relieve clinical symptom of BPS/IC and improve BPS/IC patients＇ quality of life and is well tolerated.

关 键 词：膀胱疼痛综合征/间质性膀胱炎 治疗 内镜下电灼术 

分 类 号：R694.3[医药卫生—泌尿科学]