Expressions of Osteopontin (OPN),αVβ3 and Pim-1 Associated with Poor Prognosis in Non-small Cell Lung Cancer (NSCLC)  

作　　者：Yi Jin Da-yue Tong Lu-ying Tang Jian-ning Chen Jing Zhou Zhi-ying Feng Chun-kui Shao 

机构地区：[1]Department of Pathology,the Third Affiliated Hospital,Sun Yet-sen University,Guangzhou 510630,China [2]Department of Forensic medicine,ZhongShan Medical School Sun Yet-sen University,Guangzhou 520080,China

出　　处：《Chinese Journal of Cancer Research》2012年第2期103-108,共6页中国癌症研究（英文版）

摘　　要：Objective： To examine the expressions ot osteopontin （OPN）, αvP3 and Pim-1 in non-small cell lung cancer （NSCLC）, and investigate their potential pathogenic roles in the development of NSCLC. Methods： Immunohistochemistry was used to examine the expressions of OPN, αve3 and Pim-1 in cohort （136 cases） of NSCLC samples and their adjacent normal lung tissue specimens. Statistical analysis was performed to evaluate the relationships among expressions of OPN, αve3 and Pim-1 and their associations with patients clinico- pathological parameters. Results： The expressions of OPN and Pim-1 were predominantly observed in cytoplasm. The expression of αve3 was mostly detected in cytoplasm and/or membrane. In NSCLC samples, the positive rates of OPN, αve3 and Pim-1 expressions were 68.4% （93/136）, 77.2% （105/136） and 57.4% （78/136）, respectively. In normal lung tissues, in contrast, the positive rates of OPN, αve3 and Pim-1 were 24.0% （12/50）, 26.0% （13/50） and 16.0% （8/50）, respectively. There were significant differences of the positive expression rates of OPN, αve3 and Pim-1 between NSCLCs samples and normal lung tissues （P〈O.01）. In addition, the positive expression of OPN, αve3 and Pim-1 in NSCLCs samples was significantly associated with increased pathological grade, lymph node metastasis and advanced clinical stage （P〈O.01）, and they were independent of other clinicopathological parameters （P〉0.05）. Furthermore, a significantly positive correlation between the expression of OPN and αve3 （r=0.38, P〈O.O1）, OPN and Pim-1 （r=0.37, P〈O.01）, or av133 and Pim-1 （r=0.20, P〈0.05） was evaluated in our NSCLC cohort. Conclusion： OPN, αve3 and Pim-1 proteins are frequently overexpressed in NSCLC, and they may play important roles in the development and/or progression of NSCLC.Objective： To examine the expressions ot osteopontin （OPN）, αvP3 and Pim-1 in non-small cell lung cancer （NSCLC）, and investigate their potential pathogenic roles in the development of NSCLC. Methods： Immunohistochemistry was used to examine the expressions of OPN, αve3 and Pim-1 in cohort （136 cases） of NSCLC samples and their adjacent normal lung tissue specimens. Statistical analysis was performed to evaluate the relationships among expressions of OPN, αve3 and Pim-1 and their associations with patients clinico- pathological parameters. Results： The expressions of OPN and Pim-1 were predominantly observed in cytoplasm. The expression of αve3 was mostly detected in cytoplasm and/or membrane. In NSCLC samples, the positive rates of OPN, αve3 and Pim-1 expressions were 68.4% （93/136）, 77.2% （105/136） and 57.4% （78/136）, respectively. In normal lung tissues, in contrast, the positive rates of OPN, αve3 and Pim-1 were 24.0% （12/50）, 26.0% （13/50） and 16.0% （8/50）, respectively. There were significant differences of the positive expression rates of OPN, αve3 and Pim-1 between NSCLCs samples and normal lung tissues （P〈O.01）. In addition, the positive expression of OPN, αve3 and Pim-1 in NSCLCs samples was significantly associated with increased pathological grade, lymph node metastasis and advanced clinical stage （P〈O.01）, and they were independent of other clinicopathological parameters （P〉0.05）. Furthermore, a significantly positive correlation between the expression of OPN and αve3 （r=0.38, P〈O.O1）, OPN and Pim-1 （r=0.37, P〈O.01）, or av133 and Pim-1 （r=0.20, P〈0.05） was evaluated in our NSCLC cohort. Conclusion： OPN, αve3 and Pim-1 proteins are frequently overexpressed in NSCLC, and they may play important roles in the development and/or progression of NSCLC.

关 键 词：NSCLC OPN αvl33 PIM-1 Immunohistochemistry 

分 类 号：S852.43[农业科学—基础兽医学] Q51[农业科学—兽医学]