新疆维吾尔族、汉族原发性高血压患者动脉僵硬度与尿微量白蛋白及血浆醛固酮水平的相关性  

Relationship between arterial stiffness, microalbuminuria and plasma aldosterone level in Uygurs and Hans patients with essential hypertension

作　　者：杨继贺[1] 丁琼[1] 张源明[1] 侯秀丽[1] 

机构地区：[1]新疆医科大学第一附属医院心脏中心高血压科,新疆乌鲁木齐830054

出　　处：《中华高血压杂志》2012年第6期557-560,共4页Chinese Journal of Hypertension

摘　　要：目的探讨新疆维吾尔族、汉族原发性高血压患者动脉僵硬度与尿微量白蛋白、血浆醛固酮水平的关系。方法收集2008-08-2011-04住院的原发性高血压患者共411例,其中男225例,女186例,维吾尔族123例,汉族288例,年龄(46.4±10.7)岁。对维吾尔族、汉族患者进行24h尿微量白蛋白、臂踝动脉脉搏波传导速度(baPWV)、颈动脉内膜中层厚度测定。根据baPWV水平分为正常组(baPWV≤1400cm/s,n=183)和异常组(baPWV>1400cm/s,n=228)。结果维吾尔族、汉族异常组患者24h尿微量白蛋白[维吾尔(29.23±18.44)比(14.18±4.73)mg/24h;汉(24.82±25.43)比(13.69±6.74)mg/24h,P<0.05],颈动脉内膜中层厚度[维吾尔(0.12±0.04)比(0.09±0.03)cm;汉(0.10±0.03)比(0.09±0.02)cm,P<0.05],血浆醛固酮(立位)水平[维吾尔(0.20±0.18)比(0.09±0.02)μg/L;汉(0.18±0.19)比(0.08±0.02)μg/L,P<0.05]高于正常组。经多因素Logistic回归分析显示:维吾尔族、汉族24h尿微量白蛋白,血浆醛固酮(立位)水平,颈动脉内膜中层厚度与baPWV相关(P<0.05)。结论 24h尿微量白蛋白、颈动脉内膜中层厚度及血浆醛固酮(立位)水平为维吾尔族、汉族高血压患者动脉僵硬度共同的危险因素。Objective To investigate the relationship between arterial stiffness, microalbuminuria and plasma aldo sterone level in the Uygurs and Hans patients with essential hypertension. Methods A total of 411 essential hypertensive inpatients, including 225 male, 186 female; 113 Uygurs and 288 Hans, were enrolled between Aug. 2008 and Apr. 2011. The average age of these patients was （46.4±10.7） years old. The clinical data of patients were determined, including 24 h microalbuminuria, brachial ankle pulse wave velocity（baPWV） and carotid intima media thickness. The patients were subdivided into 2 groups based on baPWV results： 163 patients in normal group （baPWV〈1400 cm/s）, and 208 patients in abnormal group （baPWV〉1400 cm/s）. Results 24 h microalbumin- uria, carotid intima media thickness, and plasma aldosterone（upright） were higher in both the Uygurs and Hans ab normalgroup than in normal group, and the result was/-Uygurs （29.23±18.44） vs （14.18±4.73） ; Hans （24.82± 25.43） vs （13.69±6.74）mg/24 h, P〈0.05][Uygurs （0.124-0.04） vs （0.09±0.03）; Hans （0.10±0.03） vs （0.09±0.02）cm, P〈0.05]; [Uygurs （0.20±0.18） vs （0.09±0.02）; Hans （0.18±0.19） vs （0.08±0.02）/,g/L, P〈0.05], respectively. Logisticreg ression analysis showed that both Uygurs and Hans baPWV were associated with 24 h microalbuminuria, carotid intima media thickness and plasma aldosterone （ upright）. Conclusion 24 h microalbuminuria, carotid intima media thickness and plasma aldosterone（upright） were common risk factors for arterial stiffness of both Uygurs and Hans patients with essential hypertension.

关 键 词：原发性高血压 尿微量白蛋白 动脉僵硬度 颈动脉内膜中层厚度 血浆醛固酮 

分 类 号：R544.1[医药卫生—心血管疾病]