国产盐酸格拉司琼注射液止吐作用的评价  

A study on antiemetic efficacy of domestic granisetron injection

作　　者：殷凯生[1] 祝浩强 钱志英[2] 胡岳隶 凌杨[3] 徐随福[4] 杨宁蓉[4] 

机构地区：[1]南京医科大学第一附属医院,江苏南京210029 [2]江苏省肿瘤医院 [3]常州市肿瘤医院 [4]解放军八一医院

出　　处：《中国癌症杂志》2000年第2期121-123,共3页China Oncology

摘　　要：Purpose:To evaluate the antiemetic efficacy and safety of domestic granisetron injection. Methods:We compared it with Metoclopramidum injection or imported Granisetron injection in 106 patients with cancer using the method of self crossover study. Results:It is shown that (1) the domestic and imported Granisetron had similar antiemitic efficacy (86.8% V 86.6%) and side effective rate (23.5% V 29.4%);(2) the effective rate of domestic Granisetron (86.8%) was significantly higher than that of Metoclopramidum (50.0%, P <0 001), and there was no significant difference in Metoclopramidum (50.0%, P <0 001),and there was no significant difference in side effect rates between Granisetron and Metoclopramidium.Conclusions:The domestic Granisetron injection is an effective and safe antiemetic drug.Purpose:To evaluate the antiemetic efficacy and safety of domestic granisetron injection. Methods:We compared it with Metoclopramidum injection or imported Granisetron injection in 106 patients with cancer using the method of self crossover study. Results:It is shown that (1) the domestic and imported Granisetron had similar antiemitic efficacy (86.8% V 86.6%) and side effective rate (23.5% V 29.4%);(2) the effective rate of domestic Granisetron (86.8%) was significantly higher than that of Metoclopramidum (50.0%, P <0 001), and there was no significant difference in Metoclopramidum (50.0%, P <0 001),and there was no significant difference in side effect rates between Granisetron and Metoclopramidium.Conclusions:The domestic Granisetron injection is an effective and safe antiemetic drug.

关 键 词：盐酸格拉司琼 止吐 有效性 安全性 

分 类 号：R975.4[医药卫生—药品]