替米沙坦对SSS双腔起搏术后阵发性心房颤动作用  

EFFECT OF TELMISARTAN ON PAROXYSMAL ATRIAL FIBRILLATION FOLLOWING DUAL-PACEMAKER IMPLANTATION IN PATIENTS WITH SICK SINUS SYNDROME

作　　者：李琳[1] 沃金善[1] 赵青[1] 郭洁[1] 程文波 

机构地区：[1]青岛大学医学院附属医院心内科,山东青岛266003 [2]上海市奉贤区中心医院心内科

出　　处：《青岛大学医学院学报》2012年第3期261-263,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的评价替米沙坦对病窦综合征(SSS)双腔起搏后阵发性心房颤动(AF)的作用。方法选择SSS行埋藏式双腔起搏器植入术后有AF发作的病人83例,随机分为治疗组(n=42)和对照组(n=41)。在治疗基础疾病的同时,治疗组病人每晚口服替米沙坦80mg,对照组病人不服用任何血管紧张素Ⅱ受体阻断剂(ARB)类药物。随访1年,观察两组AF发作次数、AF负荷及左心房内径(LAD)。结果治疗组起搏术后1年AF发作次数、AF负荷、LAD明显低于对照组(t=2.19～2.48,P<0.05),亦低于用药前(t=2.78～3.54,P<0.01),而对照组上述指标无明显变化。结论替米沙坦可有效抑制SSS双腔起搏术后阵发性AF的发生。Objective To evaluate the effect of telmisartan on paroxysmal atrial fibrillation （PAF） following dual-pace maker implantation in patients with sick sinus syndrome （SSS）. Methods Eighty-three patients with PAF after a pacemaker implantation for SSS were randomized to treatment group （n = 42） and control group （n = 41）. For patients in the treatment group, oral telmisartan 80 mg, q. n. , was given, in addition to therapy for their primary disease; for those in the control, no an- giotensin H receptor block drugs were given. During a one year follow up, the frequency of PAF,AF burden and left atrial diameter （LAD） were observed. Results During the follow-up, the frequency of PAF onset, AF burden and LAD in the treatment group were significantly lower than that in the control （t= 2.19-2.48, P〈0.05）, and that of the parameters were also lower than before treatment （t=2.78-3.54,P〈0.01）. The differences of parameters in the control group were not significant between before and after treatment. Conclusion Telmisartan can effectively inhibit the occurrence of PAF after dual-chamber pacemaker implanta- tion in patients with SSS.

关 键 词：病窦综合征 心脏起搏 人工 心房颤动 替米沙坦 

分 类 号：R541.7[医药卫生—心血管疾病] R972.2[医药卫生—内科学]