氟尿嘧啶炭纳米粒新型制剂在大鼠体内的药物动力学研究  

Study on pharmacokinetics in rat of carbo-nanoparticles new dosage form of fluorouracil

作　　者：冀强[1] 李书莲[2] 曹俊涵[3] 赵书文[3] 张丹[3] 

机构地区：[1]成都大学附属医院急诊科,成都市610041 [2]四川大学华西医院甲乳科,成都市610041 [3]四川大学华西药学院,成都市610041

出　　处：《临床合理用药杂志》2012年第19期89-91,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的对氟尿嘧啶(5-Fu)炭纳米粒新型制剂在大鼠体内进行药物动力学研究。方法采用高效液相色谱法测定大鼠经腹腔注射5-Fu炭纳米粒新剂型与普通剂型(20mg/kg体质量)后在大鼠体内的血药浓度,得出药-时曲线图及相关药物动力学参数。结果 5-Fu在0.1～100mg/L范围内,浓度与峰面积线性关系良好(r=0.9998),方法回收率为98.12%,日内和日间RSD均<12.0%。2种制剂药物体内处置均符合二室模型(W=1/C/C)。结论本文建立的5-Fu血药浓度测定方法及所获得的药物动力学参数,可为5-Fu相关制剂的临床研究提供参考;炭纳米粒新型制血药峰浓度显著大于普通剂型,且在较长时间内维持相对较高水平,有助于提高临床治疗效果。Objective To study on pharmacokinetics in rat of carbo-nanoparticles new dosage form of fluorouracil（5- Fu）. Methods Used RP-HPLC to estimate the blood concentration of 5-Fu in rat after caudal vein（20mg/kg weight） ,derived drugs-time curve and pharmacokinetic parameters. Results The calibration curve was linear（ r = O. 9998 ） within the range of 0.1 ~ 100mg/L. The method recovery was 98.12% ,within-day and between-day precision RSD were all less than 12%. After injection, the concentration-time cuvre of 5-Fu in rat plasma could be fitted to two-compartment modle（ W = 1/C/C ）. Conclusion The method for the determination of 5-Fu in plasma samples and the pharmacokinetic parameters, can provide reference for other correlated clinical treatment ;The new system of carbon nanoparticles, peak plasma concentration is significantly greater than the common dosage forms, and to maintain relatively high drug concentration levels in a long time, help to improve clinical effect.

关 键 词：氟尿嘧啶 炭纳米粒 药物动力学 大鼠 

分 类 号：R965[医药卫生—药理学]