补肾活血、泻下及开窍活血方药对老龄大鼠脑缺血再灌注多器官损伤的保护作用  

Drugs for Purgation,Reinforcing the Kidney,Inducing Resuscitation & Promoting Blood Circulation In Protection of Multi organic Injury Caused by Perfusion into Senile Rats after Cerebral Ischemia

作　　者：李建生[1] 李建国[1] 赵君玫[1] 郭盛典[1] 张卫红[1] 赵晶[1] 高爱社[1] 李申影[1] 

机构地区：[1]河南中医学院老年医学研究室,河南郑州450008

出　　处：《河南中医》2000年第3期13-16,共4页Henan Traditional Chinese Medicine

基　　金：1999年河南省杰出青年资助

摘　　要：将老龄大鼠分为模型组、对照组、益元活血丹大小剂量组、大黄组、血栓心脉宁组 ,并与尼莫地平组对照 ,观察各组老龄大鼠全脑缺血 30min再灌注 6 0min药物对脑、心、肝、肾、胃、小肠病理改变和E、NE、DA含量的作用。结果显示 ,大黄和益元活血丹及血栓心脉宁对老龄大鼠脑缺血再灌注引起多个器官损伤有不同程度的保护作用 。Senile rats are divided into model group,control group,Yi Yuan Huo Xue Dan dose group,rhubard group,Xue Shuan Xin Mai Ning group,and compared with the Nimodipine group.Observed are the pathologic changes of the brain,heart,liver,kidney,stomach,and small intestines as well as the content of E,NE and DA 30min after cerebral ischemia occurs in those rats followed by 60min of perfusion.It’s shown that rhubarb,Yi Yuan Huo Xue Dan,and Xue Shuan Xin Mai Ning have a protective action on the multi organic injury as the result of perfusion after cerebral ischemia.The mechanism has something to do with the inhibition of sympathoadreanal system excitation.

关 键 词：补肾活血 泻下 开窍活血 脑缺血 多器官衰竭 

分 类 号：R277.733.1[医药卫生—中医学] R259.905