CoQ10治疗慢性心功能不全：一项随机、双盲、对照研究  

Coenzyme Q10 for chronic heart failure： a randomized, double-blind, placebo-controlled trial

作　　者：姚秀萍[1] 李华[1] 高永艳[1] 董继红[1] 

机构地区：[1]武警总医院首保临床部,北京100039

出　　处：《中华老年多器官疾病杂志》2012年第6期435-437,共3页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的探讨辅酶Q10（CoQ10）对慢性心功能不全的疗效。方法本研究为随机、双盲、对照研究。共完成Ⅱ～Ⅲ心功能不全（心功能纽约分级）病例100例，CoQ10组50例，口服CoQ10100mg，每日一次；对照组50例，口服安慰剂100mg，1次/d；疗程3个月。结果所有患者均完成试验。经过3个月治疗后，CoQ10组患者心功能纽约心脏病学会分级较对照组明显改善（P=0．01）；CoQ10组患者6min步行距离较治疗前明显增加（P=0．045），而对照组患者6min试验步行距离无明显改善（P=0．63）；CoQ10组患者左室射血分数较治疗前有增高趋势，但无统计学差异（P=0．059）：CoQ10组患者血CoQ10水平较治疗前升高近3倍[（0．70±0．06）vs（2．15±0．26）mg／L]，而对照组则无明显升高；CoQ10组患者血清脑钠肽水平较治疗前明显降低（P=0．002），而对照组患者则无明显降低（P=0．31）。结论CoQ10可以改善Ⅱ～Ⅲ级心功能不全患者的心功能。Objective To investigate the efficacy of coenzyme Q10（CoQ10） in patients with chronic cardiac dysfunction. Methods One hundred cases with New York Heart Association （NYHA） Class II or III heart failure were enrolled in this double-blind, placebo-controlled study. Patients were randomly divided into CoQ10 group （n = 50） and control group （n = 50）, and were administrated with 100 mg/day of oral CoQ10 or placebo respectively for 3 months. Results All patients completed the trial. After 3 months of treatment, NYHA class in CoQ10 group showed a significant improvement compared with control group （P = 0.01）. There was a significant （P = 0.045） increase of the 6-min walk-test distance in CoQ10 group but no change in control group （P = 0.63） A tendency of increase of left ventricular ejection fraction was observed in CoQ10 group （P = 0.059）. There was a threefold increase of CoQ10 level in CoQ10 group [（0.70 ± 0.06） vs （2.15 ± 0.26） mg/L], but no change was observed in control group. There was a significant decrease in the serum brain natriuretic peptide level in CoQ10 group （P = 0.002）, but not in control group （P = 0.31）. Conclusions This pilot study suggests that CoQ10 therapy improves cardiac function in patients with NYHA class II or III heart failure.

关 键 词：辅酶Q10 心功能不全 临床试验 

分 类 号：R541.6[医药卫生—心血管疾病]