不同类型肥胖者血清内脂素水平与动脉硬化的相关性  

Association of Serum Visfatin and Arterial Stiffness in the Population with Different Obese Type

作　　者：宋雨[1] 丁志坚[2] 葛继勇[2] 莫婷燕[2] 

机构地区：[1]南京医科大学,江苏省南京市210029 [2]南京医科大学附属常州市第二人民医院,江苏省常州市213000

出　　处：《中国动脉硬化杂志》2012年第8期719-722,共4页Chinese Journal of Arteriosclerosis

基　　金：江苏省常州市卫生局青年课题(QN200803)

摘　　要：目的研究不同类型肥胖者血清内脂素水平与动脉硬化的关系。方法纳入1063例体检者进行横断面调查,采用生物电阻抗法测定体脂百分比及腰臀脂肪比评估肥胖,根据体脂百分比与腰臀脂肪比将所有观察者分为4组:正常体重组、正常体重+腹型肥胖组、单纯肥胖组及肥胖+腹型肥胖组;采用PWV分析仪测定肱踝脉搏波传导速度(baPWV)评估动脉僵硬度;采用酶联免疫吸附法测定血清内脂素浓度。结果正常体重+腹型肥胖组、单纯肥胖组、肥胖+腹型肥胖组血清内脂素、baPWV显著高于正常体重组(P<0.05);且在肥胖+腹型肥胖组>正常体重+腹型肥胖组>单纯肥胖组>正常体重组;血清内脂素与baPWV、收缩压、舒张压、高敏C反应蛋白呈正相关(r值分别为0.366、0.217、0.138、0.253,P<0.01)。多元线性逐步回归分析显示收缩压(P<0.01)、年龄(P<0.01)、高敏C反应蛋白(P<0.01)、血清内脂素(P<0.01)、腰臀脂肪比(P=0.001)、舒张压(P=0.01)、空腹血糖(P=0.016)是baPWV的独立影响因素,调整R2=0.765。结论腹型肥胖者血清内脂素水平显著升高,血清内脂素水平的升高与炎症、动脉僵硬度增加密切相关。内脂素可以作为肥胖者动脉硬化的预测因子。Aim To investigate the serum level of visfatin in the population with different obese type, and to an- alyse the relationship and clinical significance between visfatin and arterial stiffness. Methods The basic information was collected in a total of 1063 subjects who were enrolled by the physical examination center of the second people＇ s hospi- tal of ehangzhou. Obesity measured by bioelectric impedance analysis, and divided the study population into four groups, based on percent of body fat and waist to hip ratio ： normal, normal body weight but viscerally obese, excessive body weight but not viscerally obese, and excessive body weight and viscerally obese. Arterial stiffness was assessed by brachial-ankle PWV（baPWV）. Fasting serum visfatin was tested by ELISA. Results Comparison of the normal body weight group, the levels of serum visfatin and mean baPWV were significantly higher in the obese group, especially in the visceral- ly obese group （P 〈 0. 05 ）. The serum levels of visfatin was positively correlated with baPWV, systolic BP, diastolic BP, hs-CRP（r =0. 366, 0. 217, 0. 138, 0. 253, respectively, P 〈0.05）. In a multivariate regression analysis, haPWV was independently determined by systolic BP （ P 〈 0. 01 ）, age （ P 〈 0. 01 ）, hs-CRP （ P 〈 0. 01 ）, serum visfatin （ P 〈 0.01）, WHR（P〈0.01）, diastolic BP（P=0.01）, FPG（P=0.016）. Adjusted R2 of the model was 0.765. Con- clusion The result suggest that the elevated level of visfatin is associated with systemic inflammation and artery stiffness in viscerally obese. The visfatin may act as a prediction factor in the cardiovascular disease.

关 键 词：内脂素 肥胖 炎症 胰岛素抵抗 动脉僵硬度 

分 类 号：R5[医药卫生—内科学]