中国汉族人群ATP结合盒转运子A1基因R219K多态性与冠心病关联研究的荟瘁分析  

Meta-Analysis of ATP-Binding Cassette Transporter A1 Gene R219K Polymorphism with Coronary Heart Disease in Chinese Han Population

作　　者：张步春[1] 刘伟静[1] 李海玲[1] 李伟明[1] 徐亚伟[1] 

机构地区：[1]同济大学附属第十人民医院心内科,上海市200072

出　　处：《中国动脉硬化杂志》2012年第8期744-748,共5页Chinese Journal of Arteriosclerosis

摘　　要：目的综合评价ATP结合盒转运子A1(ABCA1)基因R219K多态性在中国汉族人群冠心病发病中的作用。方法通过文献检索收集2012年5月以前完成或发表的中国汉族人群ABCAl基因R219K多态性与冠心病相关性的病例对照研究,剔除不符合要求的文献,Egger’s检验定量评价入选文献的偏倚,并根据各入选文献结果的同质性检验结果进行数据合并,计算总OR值,Meta分析采用Stata11.0统计软件。结果共12篇文献符合条件纳入研究,包括2257例患者和2356例对照人群,入选文献无明显偏倚。Meta分析结果显示ABCA1基因R219K位点(KK+RK)/RR基因型频率的合并OR值为0.66(95%CI为0.55～0.80,P<0.0001);KK/(RK+RR)基因型频率的合并OR值为0.63(95%CI为0.53～0.75,P<0.0001)。结论 ABCAl基因R219K多态性与中国汉族人群冠心病易感性相关,K等位基因减低了冠心病发病风险。Aim To evaluate the association of ATP-binding cassette transporter A1 （ ABCA1 ） gene R219K poly- morphism with coronary heart disease （CHD） in Chinese Han population. Methods Case-control studies published before 31 May 2012 about the association of ABCAI gene R219K polymorphism and CHD in Chinese Han population were searched. All the literatures were evaluated and abstracted based on the defined selection criteria by two independent in- vestigators. Publication bias was tested by Egger＇ s test and the odd ratios of all studies were combined dependent on the result of heterogeneity test among the individual studies. The software Stata （ version 11.0 ） were used for Meta-analysis. Results A total of twelve case-control studies were collected, 2257 cases and 2356 controls were involved in the Meta-a- nalysis. The results indicated that the K219 was significantly associated with CHD （ OR = O. 66, 95% CI O. 55 - 0. 80, P 〈0. 0001 ） under dominant model and （ OR =0. 63, 95% CI 0. 53 -0. 75, P 〈0. 00001 ） under recessive model, respec- tively. No significant publication bias was found. Conclusions R219K polymorphism in ABCAI gene is associated with susceptibility of CHD and K allele might be a protective factor for CHD in Chinese Han population.

关 键 词：ATP结合盒转运子1 基因多态性 冠心病 META分析 

分 类 号：R18[医药卫生—流行病学]