甲醛接触工人肿瘤死亡流行病学  

Study on the Mortality of a Retrospective Cohort of Formaldehyde Exposed Workers in Chemical Industry

作　　者：蒋学之[1] 张瑞稳[1] 王簃兰[1] 陆培廉[1] 顾学箕[1] 

机构地区：[1]上海医科大学劳动卫生学教研室,上海200032

出　　处：《中华劳动卫生职业病杂志》1990年第5期261-264,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：中国科学院科学基金

摘　　要：采用回顾性队列死亡率研究方法,凡1977年12月31日前在5家脲醛和/或酚醛树脂生产工厂工作满一年以上的工人进入队列,失访率低于5%。观察至1987年12月31日止接触组(1316人男性813人,人年19400)。男性接触组全肿瘤,肺癌、肝癌、胃癌、膀胱癌队列。具统计学意义的超额死亡,男性接触者为全肿瘤,脑瘤、肺癌、胃癌和膀胱癌,女性为全肿瘤,肺癌和肝癌。超额死亡危险随接触工龄延长而增加,三例鼻癌均发生于接触组,工龄在10以上。纠正了吸烟因素后,接触组死亡率高于对照组。A Study on the mortality of a retrospectivc cohort on workers with morethan one year employment before Dec.31,1977 in five drea formaldehydeand/or phenol-formaldehyde resin plants was presented.The study com-pared the cancer mortalities between the observing cohort (1316 esposurerscorresponding to 29351 person year) and the control (407 non-exposurers,8959 person year) since Jan.1,1958 till Dec.31,1987.Rate of untraceablefollow-up was below 5%.Statistically significant surpass mortality were foundin all cancers;cancers of lung,brain.liver,stomach and bladder in maleexposurers;and all cancers,cancers of lung and liver in female exposurers.Riskof surpass cancer death was directly proportional to the exposure time.It is in-teresting to note that three cases of nasal cancer occurred among workers withexposure period of more than ten years.The mortality of the formaldehydeexposurers was higher than that of the non-exposurers after adjusting the ef-fect of cigarette smoking.

关 键 词：甲醛 工人 肿瘤 死亡率 流行病学 

分 类 号：R598.01[医药卫生—内科学]