社区健康中老年人颈动脉硬化的发生率及其特征研究  

The prevalence and charateristics of carotid atherosclerosis among healthy middle-aged people in community

作　　者：苏凤璋[1] 徐琳[2] 林洁明[1] 欧健苹[1] 郭黎红[1] 靳雅丽[3] 江朝强[3] 

机构地区：[1]广州市第十二人民医院超声检查科,510620 [2]香港大学公共卫生学院 [3]广州市第十二人民医院穗港英合作研究项目分子流行病研究中心

出　　处：《中华老年医学杂志》2012年第7期619-622,共4页Chinese Journal of Geriatrics

基　　金：国家自然科学基金和香港研究资助局（RGC）联合资助项目（30631160088/N-HKU720/05）

摘　　要：目的应用彩色超声多普勒探讨社区相对健康中老年人群颈动脉内-中膜厚度（CCA—IMT）和斑块（CP）形成、分布、数目与性质。方法1930例相对健康中老年人从《广州生物库队列研究》随机选取，应用彩色多普勒超声仪检测颈动脉各项指标。比较性别、年龄对颈动脉硬化的影响。结果男性CCA-IMT和CP发生率分别为41．5％（400／963）和34．1％（328／967），明显高于女性16．2％（157／967）和13．8％（i33／967）（均P〈0．001）。按年龄分为50～59岁、60～69岁和70～79岁3组，无论是男性或女性，左或右侧CCA—IMT均呈现随年龄增加而明显增厚（均P〈0．001）。颈动脉斑块形成的种类以溃疡斑（37．8％）最多见，其次分别为硬斑（24．9％）、软斑（22．1％）和扁平斑（15．2％），斑块好发部位依次是颈动脉的交叉处（61．7％）、颈总动脉（21．0％）和颈内动脉（17．3％）；50～59岁年龄组的斑块发生率女性为44．4％（83／87），明显高于男性的20．9％（108／517），而年龄在60岁或以上者则男性为79．1％（409／571），明显高于女性的55．6％（104／187）。结论年龄在60岁或以上者男性颈动脉斑块发生率高，溃疡斑最多见，斑块好发部位是颈动脉的交叉处。Objective To investigate the prevalence and charateristics of carotid atherosclerosis among healthy middle-aged people of community. Methods Totally 1930 subjects aged 50 years and above were selected randomly from 10027 participants recruited during Phase 3 of the Guangzhou Biobank Cohort Study （GBCS） . Common carotid artery intima-media thickness （CCA-IMT） and carotid plaques （CP） were measured by B-mode ultrasonography using ALT HD1 3000 mainframe with a high-resolution. Results The prevalenees of CCA-IMT and CP in men were higher than women [41.5%（400/963）vs. 16.2 （157/967）, 34.1% （328/967） vs. 13.8% （133/967） , both P〈0.001]. The prevalence of CCA-IMT was higher with age increasing in either men or women in groups of 50- yrs, 60-yrs and 70-79 yrs （all P〈0. 001）. The most of CP was cankerous spot （37.8%）, secondly hard spot （24.9%）, soft spot （22.1%） and the prevalence of flat spot was lowest （15, 2%）, The number of CP was not significantly different between the left and right side （51.0% and 49.0%）. The most common location of CP was bifurcations of carotid arteries （61.7%）, next the common carotid artery （21.0%） and internal carotid artery （ICA） was lowest （17.3%）. The prevalence of CP was 44.4% （83/87） in women aged 50- yrs, it was higher than that in men 20.9% （108/517）. However, the prevalence of CP was 79.1% （409/517） in men aged more than 60 yrs, higher than that in women （55.6%）. Conclusions The carotid atherosclerosis is commonly encountered disease in the male elderly, and the most of CP was cankerous spot in bifurcations of carotid arteries

关 键 词：颈动脉 动脉硬化 超声检查 多普勒 彩色 

分 类 号：R445.1[医药卫生—影像医学与核医学]