3-芳氧甲基/芳基-6-芳基-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑衍生物的合成及生物活性  

Synthesis of Derivatives of 3-Aryl/aryloxymethene-6-aryl-1,2,4- triazolo[3,4-b]-1,3,4-thiadiazoles and Theirs Biological Activities

作　　者：史海健[1] 王忠义[2] 史好新[1] 

机构地区：[1]安徽师范大学化学系,芜湖241000 [2]中国科技大学化学系,合肥230026

出　　处：《合成化学》2000年第3期226-230,255,共6页Chinese Journal of Synthetic Chemistry

基　　金：安徽省自然科学基金;安徽省教委基金

摘　　要：报道了 3 -芳氧甲基 /芳基 -4 -氨基 -5 -巯基 -1 ,2 ,4-三唑和芳酸在三氯氧磷作用下合成了 1 6个标题化合物。其结构经元素分析、IR,1H NMR和 MS确证。同时研究了反应条件。抗菌试验表明部分化合物具有较强的生物活性。Sixteen title compounds had been prepared by the reaction of 3-aryl/aryloxymethene-4-amino-5-mercapto-1,2,4-triazoles with aryl carboxylic acids in the presence of phosphorus oxychloride and their structures had been confirmed by elemental analysis, IR, 1H NMR and MS. These compounds were screened for their biological activities. Bacteriostatic tests indicated that some of them possess strong biological activities. The synthetic reaction conditions had also been investigated.

关 键 词：三唑并噻二唑 稠环化合物 合成 生物活性 结构 

分 类 号：O626.2[理学—有机化学] O621.29[理学—化学]