中药纤体方对营养性肥胖大鼠降脂减肥作用的实验研究  

Study on Lipid-lowering and Losing Weight of Traditional Chinese Medicine Slimming Prescription on Nutritional Obese Rats

作　　者：邓拥军[1] 肖银生[1] 徐海涛[1] 邓芬[1] 黄开秀[1] 吕丽萍[1] 

机构地区：[1]湖北省中医院,湖北武汉430074

出　　处：《湖北中医药大学学报》2012年第3期8-10,共3页Journal of Hubei University of Chinese Medicine

摘　　要：目的观察中药纤体方对营养肥胖型大鼠的降脂减肥作用。方法建立营养性肥胖大鼠模型,将大鼠分为空白对照组、模型对照组、阿托伐他汀组和中药纤体方低、中、高剂量组,各组分别灌胃给药,每天1次,连续45 d。检测血清中甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的含量以及丙二醛(MDA)、总抗氧化能力(T-AOC),记录体重、摄食量,并计算食物利用率、Lee's指数、脂体比及全视野中脂肪细胞个数。结果中药纤体方高、中剂量组能显著提高HDL-C水平和全视野脂肪细胞数量(P<0.01),降低肥胖大鼠的体重(P<0.05);高、低剂量组能显著降低肥胖大鼠的脂肪重量和脂体比(P<0.05或P<0.01)。此外,高剂量组显著降低了大鼠血清TG含量、食物利用率和Lee's指数(P<0.05或P<0.01);中剂量组显著降低了大鼠血清MDA含量(P<0.05),提高了T-AOC水平(P<0.05)。结论中药纤体方对营养性肥胖大鼠有降脂减肥和抗脂质过氧化作用。Objective To study the role of lipid - lowering and losing weight of traditional Chinese medicine slimming prescription （ZYXTF） on the nutritional obese rats. Methods After made the model of nutritional obesity rat, the experiment was divided into 6 groups as normal control group, model group, atorvastatin group, and ZYXTF group （ high - dose, medium - dose and low - dose）. Those groups were given medicine for 45 days. The content of serum triglyceride （ TG）, total cholesterol （ TC）, high - density lipoprutein （ HDL - C）, low density lipoprotein （LDL- C） and levels of malondialdehyde （MDA）, total antioxidation capacity （T- AOC） were assayed. The amount of increasing the body weight, food intake, food utilization, Lee＇s index, body fat ratio, and the quantities of fat cell in a view were observed. Results After the nutritional obesity rats were administered ZYXTF, compared with model group, the serum HDL - C and T - AOC levels were significantly higher, TG and MDA levels were significantly lower; the high fat diet rats body weight, fat weight, body fat ratio were sig- nificantly lower, the quantity of fat cell in a view was significantly increase, medium doses of Lee ＇s index was significantly lower. Conclusion Traditional Chinese medicine slimming prescription plays the role of lipid - lowering and losing weight on nutritional obese rats, and resisting lipid preoxide.

关 键 词：营养性肥胖 中药纤体方 降脂 减肥 

分 类 号：R285.5[医药卫生—中药学]