Ce(NO_3)_3对大鼠内脏组织和大脑一氧化氮及合成酶的影响  

Effect of Ce(NO_3)_3 on the Induction of NO and NOS in Rats

作　　者：杨维东[1] 刘洁生[1] 王艇[2] 雷衡毅[3] 杨燕生[3] 

机构地区：[1]暨南大学生命科技学院,广东广州510632 [2]中山大学生命科学学院,广东广州510275 [3]中山大学化学化工学院,广东广州510275

出　　处：《稀土》2000年第2期46-48,共3页Chinese Rare Earths

基　　金：国家自然科学基金!资助项目 (2 96 710 34) ;广东省自然科学基金!资助项目 (980 32 9)

摘　　要：本文研究了硝酸铈对大白鼠内脏组织、大脑及骨骼肌中一氧化氮、一氧化氮合成酶的影响。结果显示 ,腹腔注射高浓度的稀土后 ,大鼠肝脏、心脏、肾脏、骨骼肌中一氧化氮、一氧化氮合成酶的水平明显增加 ,注射低浓度的稀土后 ,肝脏、肾脏内一氧化氮的量显著增加。提示稀土能够广泛影响机体一氧化氮、一氧化氮合酶的水平 ,一氧化氮有可能参与了稀土的中毒过程。In this paper,the effect of rare earth on nitric oxide(NO) level and nitric oxide synthase (NOS) activity in rat liver,kindey,heart,muscle and brain was studied.The results showed that NO level and NOS activity was significantly increased in rat liver,kidney,heart and muscle after recurrent administration intraperitoneal of 50mg/kg cerous nitrate,at the same time,NO level was increased in rat liver and kidney after administration of 1mg/kg cerous nitrate.These suggest that the effect of rare earth on NO and NOS is extensive,and NO,as a medium,has an important role in toxicity of rare earth in vivo.

关 键 词：稀土 一氧化氮 一氧化氮合成酶 硝酸铈 生物功能 

分 类 号：S143.72[农业科学—肥料学] S816.72[农业科学—农业基础科学]