围生期足月儿高间接胆红素血症252例相关因素分析  

Analysis of related factors in 252 cases of full-term neonatal hyperbilirubinemia

作　　者：彭好[1] 蒲友华[1] 胡波[1] 刘定远[1] 袁涛[1] 

机构地区：[1]遂宁市中心医院儿科,四川遂宁629000

出　　处：《现代医药卫生》2012年第12期1795-1796,共2页Journal of Modern Medicine & Health

摘　　要：目的探讨围生期足月儿高间接胆红素血症(简称高胆)的相关因素以及高胆程度。方法对2010年3月至2011年10月收治的围生期高胆足月儿252例进行分析。结果 252例高胆患儿中,围生相关因素所致103例(40.9%),早发性母乳性黄疸63例(25.0%),ABO血型不合溶血45例(17.9%),感染相关因素所致30例(11.9%),其他11例(4.4%)。以溶血者总血清胆红素最高[(328.0±176.8)μmol/L]。252例高胆患儿中轻、中、重度分别占52.0%、33.7%、14.3%。重度高胆中围生相关因素所致11例(10.7%),ABO溶血14例(31.1%),早发性母乳性黄疸与感染相关因素所致各5例。252例中核黄疸3例,其中1例为巨大头颅血肿,2例为ABO溶血。结论围生相关因素为住院足月儿高胆的主要原因,ABO溶血是导致患儿核黄疸的主要原因。Objective To investigate the related factors and degrees of perinatal full-term neonatal hyperbilirubinemia.Methods The clinical data of 252 full-term neonates with hyperbilirubinemia treated in our hospital from March 2010 to October 2011 were analyzed.Results Among 252 cases of hyperbilirubinemia,perinatal risk factors were in 103 cases（40.9%）,early-onset breastfeeding jaundice in 63 cases（25.0%）,ABO incompatibility hemolytic diseases in 45 cases（17.9%）,infections in 30 cases（11.9%） and others in 11 cases（4.4%）.Serum total bilirubin level was the highest in newborns with hemolytic disease.The mild,moderate and severe iaundice accounted for 52.0%,33.7% and 14.3% respectively.Among severe jaundice,ABO hemolytic disease was in 14 cases（31.1%）,the perinatal risk factors in 11 cases（10.7%）,infections in 5 cases and early-onset breastfeeding jaundice in 5 cases.Among 3 cases of kernicterus,1 case was giant cephalohematoma and 2 cases were ABO incompatibility hemolytic diseases.Conclusion The perinatal related factors are the main causes of full-term neonatal hyperbilirubinemia and ABO incompatibility hemolytic diseases is the main cause leading to kernicterus.

关 键 词：胆红素/血液 高胆红素血症 新生儿 婴儿 新生 围生医学 

分 类 号：R722.17[医药卫生—儿科]