100749例新生儿中先天性甲状腺功能减低症筛查结果分析  

Analysis of screening results of congential hypothyroidism among 100 749 infants inBaoding city

作　　者：殷会芳[1] 王红英[1] 

机构地区：[1]保定市妇幼保健院新筛室,河北071000

出　　处：《中国优生与遗传杂志》2012年第6期73-75,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的分析2011年1月-2011年11月保定地区新生儿先天性甲状腺功能减低症(CH)的发病特点。方法对此时间段内由市,各区,县医疗保健单位送往保定市新生儿疾病筛查中心的新生儿足跟血滤纸干血片100 749人份,(生后3-7天采血,滴于S&903S型滤纸上)采用时间分辨荧光免疫技术,检测干血斑中促甲状腺素(hTSH)含量,将复查可疑阳性患儿召回,通过血清学甲功五项检测(电化学发光法)进行确诊。结果 100 749人新生儿中,筛查出可疑阳性患儿1856人,男998人,女858人,筛查阳性率1.84%,召回1548人,召回率83.4%,确诊CH患儿42人,男21人,女21人,检出率约1/2399,与2008年报道的检出率1/3333相比有所上升。其中1月发病率最低,4月最高,1月～4月呈上升趋势,6、9、11月发病较低,其余月较高。结论新生儿筛查是早期发现先天性甲状腺功能减低症患儿的重要手段,2011年1月～11月期间,CH发病率比以往高,9月～11月是筛查高峰期,但不是发病高峰期,1月～4月发病率呈上升趋势,其余月无规律。Objective： To analyse the characteristic of new borns with congential hypothyroidism（CH） in Baoding city on January-November 2011.Methods： Heel blood sample was droped on S 903S type filter paper from neonate order than 3 days after birth on local hospital and sent to the center of neonatal disease screening in Baoding city.hTSH levels at dried blood samples from 100 749 was measured by Time-resolved fluoroimmunoassay,the concentration of TSH,T3,T4,fT3 and fT4 in serum from suspect infants was tested by chemiluminesence.Results： 42 among 100 749 were diagnosed as CH,the ratio of boys to girls was 1∶1,the incidence was 1/2399 and higher than it before.Also,July-September were the peak of screening,the first months in incidence was the lowest,April the highest,January-April gradually rised,another were not law.Conclusion： An elevated hTSH concentration in infant blood is the earliest available laboratory manifestation of primary hypothyroidism,September-Novemberr in 2011 were the peak of screening,instead of diagnosic peak.

关 键 词：新生儿 先天性甲状腺功能减低症 筛查 

分 类 号：R722.1[医药卫生—儿科]