抗苗勒管激素对卵巢低反应预测价值的研究  

Study of anti-Müllerian hormone in prediction of poor ovarian response

作　　者：朱英哲[1] 彭沙[2] 王青欣[2] 杨晓葵[2] 

机构地区：[1]首都医科大学附属北京妇产医院检验科,北京100026 [2]首都医科大学附属北京妇产医院生殖医学科,北京100026

出　　处：《中国优生与遗传杂志》2012年第6期105-107,共3页Chinese Journal of Birth Health & Heredity

基　　金：北京市卫生局"十百千"项目;国家人事部留学人员科技活动择优资助项目

摘　　要：目的探讨抗苗勒氏管激素(AMH)在辅助生殖技术(ART)中对控制性超排卵(COH)卵巢低反应的预测价值。方法利用ELISA法对181例首次接受IVF/ICSI-ET治疗的不孕症患者基础血清AMH蛋白水平(bAMH)进行检测。根据患者COH卵巢反应将患者分为2组:卵巢低反应组20例(获卵数≤5个)和卵巢反应良好组161例(获卵数>5个)。比较bAMH与年龄、获卵数、基础FSH等的相关性。结果①181例不孕症患者bAMH水平与获卵数呈显著正相关(r=0.709,P<0.05);②卵巢低反应组(获卵数≤5个)与反应良好组(获卵数>5个)的bAMH水平比较,差异有统计学意义(P<0.05);③受试者工作特征(ROC)曲线分析显示,bAMH水平的曲线下面积(AUC)为0.949。当bAMH截断值≤3.65ng/ml时,灵敏度为86.3%,特异度为90.0%。结论 AMH与卵巢反应性有关,可以在辅助生殖技术中作为评价预测COH中卵巢低反应的血清学标记物。Objective： To evaluate anti-Müllerian hormone（AMH） in prediction of poor ovarian response to controlled ovarian hyperstimulation（COH） in assisted reproductive technology（ART）.Methods： The level of bAMH protein secretion in serum was examined by ELISA in 181 cases of infertile woman with first cycle of in vitro fertilization（IVF）/ intracytoplasmic sperm injection（ICSI）.The patients were classified into 2 groups including poor response（n=20,the number of oocytes retrieved≤5） and normal response（n=161,the number of oocytes retrieved5） according to ovarian response to COH.The relationship among bAMH level,age and the number of oocytes retrieved was analyzed by software engineering SPSS11.5.Results： ① A positive correlation was found between serum bAMH and the number of oocytes retrieved（r=0.709,P0.05） in 181 cases of infertile women.② The serum bAMH level of patients with poor ovarian response（the number of oocytes retrieved≤5） was significantly lower than that of patients with normal ovarian response（the number of oocytes retrieved5）（P0.05）.③ ROC curve analysis revealed that area under curve（AUC）was 0.949 for bAMH.The sensitivity and specificity were 86.3%and 90.0%,respectively when the cutoff value of bAMH was no higher than 3.65ng/ml.Conclusion： These results indicate that serum AMH represents the well endocrine marker to assess the poor ovarian response on COH in ART.

关 键 词：血清抗苗勒管激素 控制性超排卵 卵巢反应性 

分 类 号：R714.8[医药卫生—妇产科学]