RANTES基因多态性与子宫内膜异位症的相关性研究  

Relationship between endometriosis and RANTES genetic polymorphism

作　　者：曾秀华[1] 周明[1] 鲁爱民[1] 王春平[1] 许学岚[1] 石瑾秋[1] 

机构地区：[1]深圳市罗湖区人民医院,广东518001

出　　处：《中国优生与遗传杂志》2012年第7期34-35,45,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的研究RANTES基因启动子区-28C/G的多态性与子宫内膜异位症的关系。方法应用聚合酶链反应-限制性酶切片段长度多态性技术(PCR-RFLP)并进行测序的方法检测子宫内膜异位症患者46例(内异症组),非子宫内膜异位症患者35例(对照组)。结果子宫内膜异症组RANTES-28C/C、C/G两种基因型分布频率分别为84.78%、15.22%,对照组RANTES-28C/C、C/G两种基因型分布频率分别为85.71%、14.29%;两组间的组之间的基因型分布频率比较差异无显著性(P>0.05)。RANTES基因-28位点C、G等位基因型在内异症组中的分布频率分别为92.39%、7.61%,在对照组中分别为92.86%、7.14%,两组间等位基因型频率比较差异无统计学意义(P>0.05)。结论 RAN-TES启动子区-28C/G基因多态性与子宫内膜异位症遗传易感性无关联。Objective： To investigate the association of RANTES genetic polymorphism with endometriosis. Methods： PCR - PFLP technique and Sequencing method was used to detect C/G single nucleotide polymorphisms of -28 locus in RANTES gene of 46 women with endometriosis （endometriosis group） and 35 women without endometriosis （control group）. Results： In endometriosis group, the distribution frequencies of C/C genotype and C/G genotype of - 28 locus in RANTES gene were 84.78% and 15.22%, respectively; in control group, the distribution frequencies of C/C genotype and C/G genotype of - 28 locus in RANTES gene were 85.71% and 4. 29%, respectively, there was no significant difference between the two groups （P 〉 0.05）. The distribution frequen- cies of C allele and G allele of -28 locus in RANTES gene were 92. 39% and 7.61% in endometriosis group, 92. 86% and 7. 14% in control group, respectively, there was no significant difference between the two groups （P 〉 0. 05）. Conclusions： C/G polymor phism of - 28 locus in RANTES gene may be independent of hereditary susceptibility of endometriosis.

关 键 词：子宫内膜异位症 RANTES 基因多态性 

分 类 号：R711.71[医药卫生—妇产科学]